SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		5 / 12 GLY A  84
GLY A  82
ARG A 170
PRO A  57
LYS A  56
 None
 0.97A 1y4lA-2wfiA:
undetectable		 1y4lA-2wfiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 6 PHE A  65
ILE A  14
VAL A  24
PHE A  26
 None
 0.92A 2cizA-2wfiA:
undetectable		 2cizA-2wfiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 6 PHE A  26
PHE A  40
GLY A  76
GLY A  77
 None
None
OCS  A  63 ( 4.5A)
OCS  A  63 ( 3.2A)
 0.80A 2qr2A-2wfiA:
undetectable
2qr2B-2wfiA:
undetectable		 2qr2A-2wfiA:
24.57
2qr2B-2wfiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 5 GLY A  76
GLY A  77
PHE A  26
PHE A  40
 OCS  A  63 ( 4.5A)
OCS  A  63 ( 3.2A)
None
None
 0.74A 2qr2A-2wfiA:
undetectable
2qr2B-2wfiA:
undetectable		 2qr2A-2wfiA:
24.57
2qr2B-2wfiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 8 PHE A  26
PHE A  40
GLY A  76
GLY A  77
 None
None
OCS  A  63 ( 4.5A)
OCS  A  63 ( 3.2A)
 0.70A 2qx4A-2wfiA:
undetectable
2qx4B-2wfiA:
undetectable		 2qx4A-2wfiA:
24.57
2qx4B-2wfiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 6 PHE A  26
PHE A  40
GLY A  76
GLY A  77
 None
None
OCS  A  63 ( 4.5A)
OCS  A  63 ( 3.2A)
 0.70A 2qx6A-2wfiA:
undetectable
2qx6B-2wfiA:
undetectable		 2qx6A-2wfiA:
24.57
2qx6B-2wfiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 8 GLY A  87
GLY A  86
GLY A  84
SER A 122
 None
 0.64A 3d41A-2wfiA:
undetectable		 3d41A-2wfiA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 6 THR A 131
SER A 111
LEU A 109
THR A 127
 None
 0.84A 3deuB-2wfiA:
undetectable		 3deuB-2wfiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		3 / 3 SER A 146
GLY A 147
GLN A 148
 None
 0.49A 3v4tH-2wfiA:
undetectable		 3v4tH-2wfiA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		5 / 12 GLY A  22
GLN A  19
ILE A  14
VAL A 150
ILE A 154
 None
 0.99A 4ax8A-2wfiA:
undetectable		 4ax8A-2wfiA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		4 / 6 ARG A 115
GLY A 116
GLN A  75
MET A  73
 None
MG  A1002 ( 4.8A)
None
None
 1.24A 4g0vB-2wfiA:
undetectable		 4g0vB-2wfiA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		5 / 12 GLY A  22
GLN A  19
ILE A  14
VAL A 150
ILE A 154
 None
 0.96A 4uw0A-2wfiA:
undetectable		 4uw0A-2wfiA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G
(Homo
sapiens) 		5 / 12 GLY A 121
ILE A  90
ASN A 114
PHE A  40
LEU A 110
 None
None
MG  A1002 ( 4.7A)
None
None
 0.98A 5fa8A-2wfiA:
undetectable		 5fa8A-2wfiA:
23.76