SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2wfo GLYCOPROTEIN 1
(Machupo
mammarenavirus) 		3 / 3 LEU A 132
SER A 141
ASN A 137
 None
None
NAG  A1243 (-1.8A)
 0.79A 1bx4A-2wfoA:
undetectable		 1bx4A-2wfoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2wfo GLYCOPROTEIN 1
(Machupo
mammarenavirus) 		4 / 6 LEU A 152
ASN A  96
ILE A 179
PHE A 177
 None
 1.21A 2jn3A-2wfoA:
undetectable		 2jn3A-2wfoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2wfo GLYCOPROTEIN 1
(Machupo
mammarenavirus) 		3 / 3 VAL A 187
GLY A 189
LYS A 181
 None
 0.77A 4k50I-2wfoA:
undetectable		 4k50I-2wfoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wfo GLYCOPROTEIN 1
(Machupo
mammarenavirus) 		5 / 11 ASP A 222
SER A 224
VAL A 215
ILE A 217
ASN A 174
 NAG  A1243 ( 4.1A)
None
None
None
None
 1.30A 5y80A-2wfoA:
undetectable		 5y80A-2wfoA:
18.52