SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 319
LEU B 357
LEU B 284
GLY B 283
 None
 0.80A 1n13D-2wfxB:
undetectable
1n13E-2wfxB:
undetectable		 1n13D-2wfxB:
12.11
1n13E-2wfxB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 10 VAL B 562
GLN B 220
LEU B 535
VAL B 510
LEU B 505
 None
 0.98A 3gwxA-2wfxB:
undetectable		 3gwxA-2wfxB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 VAL B 334
ARG B 241
VAL B 251
PHE B 243
 None
 1.45A 3jx4A-2wfxB:
undetectable
3jx4B-2wfxB:
undetectable		 3jx4A-2wfxB:
22.92
3jx4B-2wfxB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 GLY B 372
GLU B 347
ASP B 378
ASP B 431
 None
 1.38A 3mb5A-2wfxB:
undetectable		 3mb5A-2wfxB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 10 THR B 399
VAL B 397
LEU B 343
VAL B 341
PHE B 388
 None
 1.42A 3tbgC-2wfxB:
undetectable		 3tbgC-2wfxB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 LEU B 266
TYR B 303
LEU B 299
TYR B 265
 None
 0.91A 3v81A-2wfxB:
undetectable		 3v81A-2wfxB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 266
TYR B 303
LEU B 299
TYR B 265
 None
 0.98A 4b3qA-2wfxB:
undetectable		 4b3qA-2wfxB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 TYR B 293
HIS B 332
ARG B 241
 None
 0.99A 4htfA-2wfxB:
undetectable		 4htfA-2wfxB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA B 436
PHE B 554
PHE B 486
LEU B 491
GLY B 433
 None
None
None
None
CA  B1670 ( 4.7A)
 0.95A 4o3fA-2wfxB:
undetectable		 4o3fA-2wfxB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 TYR B 509
THR B 442
GLN B 523
LEU B 451
 None
 1.50A 4qzuC-2wfxB:
undetectable		 4qzuC-2wfxB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 VAL B 334
ARG B 241
VAL B 251
PHE B 243
 None
 1.42A 5addA-2wfxB:
undetectable
5addB-2wfxB:
undetectable		 5addA-2wfxB:
22.92
5addB-2wfxB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 VAL B 334
ARG B 241
VAL B 251
PHE B 243
 None
 1.43A 5adeA-2wfxB:
undetectable
5adeB-2wfxB:
undetectable		 5adeA-2wfxB:
22.92
5adeB-2wfxB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 GLY B 275
GLN B 273
LYS B 247
 None
 0.70A 5imsB-2wfxB:
undetectable		 5imsB-2wfxB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 555
ILE B 551
VAL B 492
GLY B 494
ILE B 564
 None
 0.91A 5t8hB-2wfxB:
undetectable		 5t8hB-2wfxB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA B 436
GLY B 493
GLY B 512
ILE B 551
LEU B 579
 None
 1.16A 5ul4A-2wfxB:
undetectable		 5ul4A-2wfxB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 GLN B 356
GLY B 355
GLN B 228
ASP B 431
 None
 1.16A 5vlmE-2wfxB:
undetectable		 5vlmE-2wfxB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 ILE B 253
PHE B 243
TYR B 293
THR B 325
 None
 1.11A 5z84N-2wfxB:
undetectable
5z84W-2wfxB:
undetectable		 5z84N-2wfxB:
19.85
5z84W-2wfxB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 GLY B 390
ASP B 371
ARG B 464
GLN B 356
 None
 1.27A 5zrfB-2wfxB:
undetectable		 5zrfB-2wfxB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 PHE B 289
LEU B 245
VAL B 251
VAL B 334
 None
 1.05A 6cp4A-2wfxB:
undetectable		 6cp4A-2wfxB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 ALA B 436
TYR B 509
GLN B 467
ILE B 465
 None
 1.46A 6g9bA-2wfxB:
undetectable
6g9bB-2wfxB:
undetectable		 6g9bA-2wfxB:
11.61
6g9bB-2wfxB:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 GLY B 512
GLY B 433
SER B 453
ALA B 463
 None
CA  B1670 ( 4.7A)
None
None
 0.73A 6hu9H-2wfxB:
undetectable
6hu9e-2wfxB:
undetectable		 6hu9H-2wfxB:
10.98
6hu9e-2wfxB:
13.13