SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NT2_A_SAMA301_0 (FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	5 / 12	GLY A 128 ALA A 146 SER A 185 ALA A 95 ASP A 148	None None None None ZN A1199 (-2.0A)	1.20A	1nt2A-2wg3A: undetectable	1nt2A-2wg3A: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_A_ACTA1117_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	3 / 3	ASP A 189 ARG A 145 ARG A 102	None	1.06A	2j9dA-2wg3A: 2.7 2j9dC-2wg3A: 2.3	2j9dA-2wg3A: 22.36 2j9dC-2wg3A: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_B_SAMB300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	3 / 3	TYR A 175 ASP A 148 ASP A 130	None ZN A1199 (-2.0A) None	0.91A	3ou6B-2wg3A: undetectable	3ou6B-2wg3A: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S8P_A_SAMA500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	3 / 3	HIS A 141 SER A 60 GLU A 54	ZN A1199 (-3.3A) None None	0.68A	3s8pA-2wg3A: undetectable	3s8pA-2wg3A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TZF_B_08DB280_1 (7,8-DIHYDROPTEROATE SYNTHASE)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	4 / 8	THR A 56 ARG A 55 PRO A 62 LYS A 187	None	1.09A	3tzfB-2wg3A: undetectable	3tzfB-2wg3A: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AK3_A_P2EA1201_1 (PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562)	2wg3	DESERT HEDGEHOG PROTEIN N-PRODUCT (Homo sapiens)	4 / 4	PRO A 83 MET A 99 GLY A 128 VAL A 107	None	1.33A	6ak3A-2wg3A: undetectable	6ak3A-2wg3A: 24.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NT2_A_SAMA301_0","FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",5,"GLY A 128;ALA A 146;SER A 185;ALA A  95;ASP A 148","None;None;None;None; ZN A1199 (-2.0A)","1.20A","1nt2A-2wg3A:undetectable","1nt2A-2wg3A:21.26"],["2J9D_A_ACTA1117_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",3,"ASP A 189;ARG A 145;ARG A 102","None","1.06A","2j9dA-2wg3A:2.7;2j9dC-2wg3A:2.3","2j9dA-2wg3A:22.36;2j9dC-2wg3A:22.36"],["3OU6_B_SAMB300_1","SAM-DEPENDENT METHYLTRANSFERASE","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",3,"TYR A 175;ASP A 148;ASP A 130","None; ZN A1199 (-2.0A);None","0.91A","3ou6B-2wg3A:undetectable","3ou6B-2wg3A:22.81"],["3S8P_A_SAMA500_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",3,"HIS A 141;SER A  60;GLU A  54"," ZN A1199 (-3.3A);None;None","0.68A","3s8pA-2wg3A:undetectable","3s8pA-2wg3A:19.27"],["3TZF_B_08DB280_1","7,8-DIHYDROPTEROATE SYNTHASE","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",4,"THR A  56;ARG A  55;PRO A  62;LYS A 187","None","1.09A","3tzfB-2wg3A:undetectable","3tzfB-2wg3A:20.58"],["6AK3_A_P2EA1201_1","PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562","2wg3","DESERT HEDGEHOG PROTEIN N-PRODUCT","Homo sapiens",4,"PRO A  83;MET A  99;GLY A 128;VAL A 107","None","1.33A","6ak3A-2wg3A:undetectable","6ak3A-2wg3A:24.14"]]