SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A  48
ILE A  37
ALA A  41
VAL A  43
 None
 0.40A 2xrzB-2wgbA:
undetectable		 2xrzB-2wgbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  88
GLU A  93
ILE A 175
MET A 176
 None
 0.92A 4ww7A-2wgbA:
undetectable		 4ww7A-2wgbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A  12
LEU A  19
ARG A  64
ARG A  15
 None
None
SO4  A1186 (-3.0A)
None
 1.09A 5l6eA-2wgbA:
undetectable
5l6eB-2wgbA:
undetectable		 5l6eA-2wgbA:
21.65
5l6eB-2wgbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 171
ALA A 174
ILE A 175
ALA A 157
LEU A 154
 None
 1.01A 5mvmA-2wgbA:
2.6
5mvmE-2wgbA:
2.6		 5mvmA-2wgbA:
17.71
5mvmE-2wgbA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 121
ILE A 101
ASP A 125
GLY A 124
 None
 0.99A 5x5qE-2wgbA:
undetectable		 5x5qE-2wgbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 MET A 155
ARG A 148
TRP A 152
LEU A 132
 None
 1.16A 6fosB-2wgbA:
undetectable		 6fosB-2wgbA:
16.32