SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.80A 1c9sI-2wghA:
undetectable
1c9sJ-2wghA:
undetectable		 1c9sI-2wghA:
8.38
1c9sJ-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.80A 1c9sU-2wghA:
undetectable
1c9sV-2wghA:
undetectable		 1c9sU-2wghA:
8.38
1c9sV-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 593
ALA A 539
GLN A 417
ILE A 481
ASN A 495
 None
 1.02A 1dhfB-2wghA:
undetectable		 1dhfB-2wghA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.72A 1gtnA-2wghA:
undetectable
1gtnK-2wghA:
undetectable		 1gtnA-2wghA:
8.38
1gtnK-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.77A 1gtnA-2wghA:
undetectable
1gtnB-2wghA:
undetectable		 1gtnA-2wghA:
8.38
1gtnB-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.75A 1gtnE-2wghA:
undetectable
1gtnF-2wghA:
undetectable		 1gtnE-2wghA:
8.38
1gtnF-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.08A 1odiA-2wghA:
undetectable		 1odiA-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.16A 1odiB-2wghA:
undetectable		 1odiB-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.17A 1odiC-2wghA:
undetectable		 1odiC-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.14A 1odiD-2wghA:
undetectable		 1odiD-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.08A 1odiE-2wghA:
undetectable		 1odiE-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.11A 1odiF-2wghA:
undetectable		 1odiF-2wghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 558
ILE A 593
ILE A 588
GLY A 564
ILE A 565
 None
 0.80A 1sguB-2wghA:
undetectable		 1sguB-2wghA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.79A 1utdB-2wghA:
undetectable
1utdC-2wghA:
undetectable		 1utdB-2wghA:
8.38
1utdC-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.78A 1utdF-2wghA:
undetectable
1utdG-2wghA:
undetectable		 1utdF-2wghA:
8.38
1utdG-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.81A 1utdJ-2wghA:
undetectable
1utdK-2wghA:
undetectable		 1utdJ-2wghA:
8.38
1utdK-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 HIS A 179
ASP A 482
ASN A 495
 None
 0.77A 1wg8B-2wghA:
undetectable		 1wg8B-2wghA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 256
SER A 373
TYR A 371
 DTP  A1745 (-3.0A)
None
None
 0.58A 1x70A-2wghA:
2.2		 1x70A-2wghA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 527
ASN A 528
LEU A 526
LEU A 578
LEU A 466
 None
 1.29A 1zucB-2wghA:
undetectable		 1zucB-2wghA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 538
ALA A 539
ILE A 501
ALA A 447
ILE A 503
 None
None
None
GOL  A1743 (-4.9A)
None
 0.87A 2b60A-2wghA:
undetectable		 2b60A-2wghA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.99A 2c8aB-2wghA:
undetectable		 2c8aB-2wghA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.98A 2c8aD-2wghA:
undetectable		 2c8aD-2wghA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A 198
THR A 189
LEU A 477
VAL A 174
 None
 1.07A 2cppA-2wghA:
undetectable		 2cppA-2wghA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 SER A 606
THR A 199
VAL A 174
ALA A 208
THR A 210
 GOL  A1743 (-4.4A)
GOL  A1743 ( 4.8A)
None
None
None
 1.17A 2nniA-2wghA:
undetectable		 2nniA-2wghA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 538
ALA A 539
ILE A 501
ALA A 447
ILE A 503
 None
None
None
GOL  A1743 (-4.9A)
None
 0.81A 2rkfB-2wghA:
undetectable		 2rkfB-2wghA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 497
GLU A 440
SER A 543
 None
 0.86A 2xctD-2wghA:
undetectable		 2xctD-2wghA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 259
GLY A 271
LEU A 272
HIS A 305
PRO A 353
 None
 1.08A 2y7kD-2wghA:
undetectable		 2y7kD-2wghA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 508
ALA A 524
VAL A 505
GLN A 706
PHE A 519
 None
 1.27A 3bszE-2wghA:
undetectable		 3bszE-2wghA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 664
ILE A 669
ASN A 638
LEU A 641
LEU A 645
 None
 1.18A 3cjtG-2wghA:
undetectable		 3cjtG-2wghA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 527
ASN A 528
LEU A 526
LEU A 578
LEU A 466
 None
 1.31A 3d90B-2wghA:
undetectable		 3d90B-2wghA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 TYR A 279
PHE A 297
GLN A 288
GLY A 249
 None
 0.95A 3hjoA-2wghA:
undetectable		 3hjoA-2wghA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 473
LEU A 477
ILE A 535
GLY A 538
ALA A 539
 None
 1.05A 3kk6A-2wghA:
undetectable		 3kk6A-2wghA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 9 TYR A 279
PHE A 297
GLN A 288
VAL A 441
GLY A 249
 None
 1.05A 3km6B-2wghA:
undetectable		 3km6B-2wghA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 595
ASN A 495
GLU A 434
 None
 0.85A 3kpdC-2wghA:
undetectable		 3kpdC-2wghA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 595
ASN A 495
GLU A 434
 None
 0.86A 3kpdB-2wghA:
undetectable		 3kpdB-2wghA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.05A 3uawA-2wghA:
undetectable		 3uawA-2wghA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 10 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.00A 3uayA-2wghA:
undetectable		 3uayA-2wghA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 450
ASN A 452
ILE A 501
PHE A 198
HIS A 200
 None
 1.37A 3w37A-2wghA:
2.4		 3w37A-2wghA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 450
ASN A 452
ILE A 501
PHE A 198
HIS A 200
 None
 1.36A 3welA-2wghA:
3.7		 3welA-2wghA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 540
GLU A 541
SER A 543
 None
 0.75A 4ccqA-2wghA:
undetectable		 4ccqA-2wghA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 528
LEU A 466
PHE A 701
 None
 0.68A 4dajB-2wghA:
undetectable		 4dajB-2wghA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 508
LEU A 451
LEU A 466
ILE A 617
GLN A 706
 None
 1.20A 4f4dA-2wghA:
undetectable		 4f4dA-2wghA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 ARG A 516
ASP A 675
ASP A 644
ARG A 648
 None
 1.39A 4kcnA-2wghA:
undetectable		 4kcnA-2wghA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 ARG A 516
ASP A 675
ASP A 644
ARG A 648
 None
 1.39A 4kcnB-2wghA:
2.6		 4kcnB-2wghA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 171
ASN A 452
ASN A 613
LEU A 611
GLN A 506
 None
 1.40A 4kuoA-2wghA:
undetectable		 4kuoA-2wghA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 193
ASN A 452
ASN A 613
LEU A 611
GLN A 506
 None
 1.45A 4kuoA-2wghA:
undetectable		 4kuoA-2wghA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 TRP A 581
ALA A 700
THR A 470
VAL A 474
 None
 1.00A 4ltwA-2wghA:
undetectable		 4ltwA-2wghA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ASN A 484
ASP A 482
SER A 175
HIS A 179
ASN A 478
 None
 1.33A 4pooB-2wghA:
undetectable		 4pooB-2wghA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 608
GLY A 507
ILE A 702
ALA A 600
GLY A 504
 None
 0.88A 4r29D-2wghA:
undetectable		 4r29D-2wghA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 TYR A 568
ASP A 569
TYR A 536
TRP A 581
 None
 1.42A 5e2iA-2wghA:
undetectable		 5e2iA-2wghA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 480
ALA A 447
LEU A 205
THR A 189
ILE A 178
 None
GOL  A1743 (-4.9A)
None
None
None
 0.98A 5e8qA-2wghA:
undetectable		 5e8qA-2wghA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ILE A 669
PRO A 670
ILE A 672
 None
 0.46A 5hw8F-2wghA:
undetectable		 5hw8F-2wghA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A 689
LYS A 719
SER A 722
 None
 1.36A 5odiA-2wghA:
2.4		 5odiA-2wghA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 ARG A 341
PRO A 335
PHE A 367
GLU A 368
 None
 1.41A 5odqA-2wghA:
undetectable		 5odqA-2wghA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 131
VAL A 176
ILE A 178
LEU A 205
THR A 204
 None
 1.27A 5tiwB-2wghA:
undetectable		 5tiwB-2wghA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 9 GLY A 295
ILE A 248
GLY A 247
LEU A 428
PHE A 311
 None
 0.99A 5vkqC-2wghA:
undetectable
5vkqD-2wghA:
undetectable		 5vkqC-2wghA:
17.03
5vkqD-2wghA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 0.96A 5vlmB-2wghA:
undetectable		 5vlmB-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.08A 5vlmE-2wghA:
undetectable		 5vlmE-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.16A 5vlmG-2wghA:
undetectable		 5vlmG-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 TYR A 680
ASP A 675
ASP A 644
 None
 0.83A 5x6yA-2wghA:
undetectable		 5x6yA-2wghA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 179
ASN A 478
VAL A 473
LEU A 192
 None
 1.29A 5xdhA-2wghA:
undetectable
5xdhC-2wghA:
undetectable		 5xdhA-2wghA:
9.23
5xdhC-2wghA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
 None
 1.42A 6mxtA-2wghA:
undetectable		 6mxtA-2wghA:
22.38