SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14
(Homo
sapiens) 		3 / 3 ARG A 117
VAL A 147
GLY A  25
 PO4  A 200 (-3.9A)
None
None
 0.57A 2avvE-2wgpA:
undetectable		 2avvE-2wgpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14
(Homo
sapiens) 		3 / 3 GLU A 186
TYR A 185
ARG A 149
 None
 0.77A 5uunB-2wgpA:
undetectable		 5uunB-2wgpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14
(Homo
sapiens) 		3 / 3 ARG A 163
ILE A 159
SER A 169
 None
 0.87A 5zw2A-2wgpA:
undetectable		 5zw2A-2wgpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14
(Homo
sapiens) 		5 / 9 LEU A  36
VAL A 141
PHE A 154
LEU A 158
ILE A 123
 None
 1.35A 6fdyU-2wgpA:
undetectable		 6fdyU-2wgpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14
(Homo
sapiens) 		4 / 8 GLN A  70
TYR A  73
ALA A  42
VAL A  41
 None
 1.02A 6hu9a-2wgpA:
undetectable
6hu9e-2wgpA:
undetectable		 6hu9a-2wgpA:
18.20
6hu9e-2wgpA:
21.16