SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.82A 1a7yA-2wgrA:
undetectable		 1a7yA-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.82A 1i3wE-2wgrA:
undetectable		 1i3wE-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.86A 1i3wE-2wgrA:
undetectable		 1i3wE-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.79A 1i3wF-2wgrA:
undetectable		 1i3wF-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.87A 1i3wG-2wgrA:
undetectable		 1i3wG-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.86A 1i3wG-2wgrA:
undetectable		 1i3wG-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.83A 1mnvD-2wgrA:
undetectable		 1mnvD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.76A 1mnvD-2wgrA:
undetectable		 1mnvD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.83A 1ovfB-2wgrA:
undetectable		 1ovfB-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.79A 1qfiA-2wgrA:
undetectable		 1qfiA-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.84A 1unjF-2wgrA:
undetectable		 1unjF-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		4 / 8 HIS A  57
GLN A  54
TYR A  29
ARG A  66
 None
 1.45A 2vxaH-2wgrA:
undetectable
2vxaJ-2wgrA:
undetectable
2vxaK-2wgrA:
undetectable		 2vxaH-2wgrA:
19.05
2vxaJ-2wgrA:
19.05
2vxaK-2wgrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		5 / 12 GLU A  83
ILE A  19
PHE A 101
PHE A  98
ALA A  84
 None
 1.31A 3ndiA-2wgrA:
undetectable		 3ndiA-2wgrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		5 / 12 PHE A  70
ILE A  11
LEU A 114
VAL A  22
VAL A  16
 None
 1.02A 3rukA-2wgrA:
undetectable		 3rukA-2wgrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.88A 4hivD-2wgrA:
undetectable		 4hivD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		4 / 5 PHE A 117
ILE A  11
GLN A 122
ARG A 121
 None
 1.23A 5jm4A-2wgrA:
undetectable		 5jm4A-2wgrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		4 / 4 PHE A 117
ILE A  11
GLN A 122
ARG A 121
 None
 1.33A 5jm4B-2wgrA:
undetectable		 5jm4B-2wgrA:
22.27