SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 253
SER A 255
MET A 256
LEU A 259
LEU A 283
 None
IPA  A1408 (-4.2A)
IPA  A1408 (-3.1A)
None
None
 1.15A 1a8uA-2wgyA:
undetectable		 1a8uA-2wgyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 253
SER A 255
MET A 256
LEU A 259
LEU A 283
 None
IPA  A1408 (-4.2A)
IPA  A1408 (-3.1A)
None
None
 1.17A 1a8uB-2wgyA:
undetectable		 1a8uB-2wgyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 0.94A 1eqhA-2wgyA:
undetectable		 1eqhA-2wgyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 0.95A 1eqhB-2wgyA:
undetectable		 1eqhB-2wgyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 236
LEU A 156
GLY A 107
ASP A 211
 None
 1.00A 1rmtC-2wgyA:
undetectable		 1rmtC-2wgyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  59
HIS A  52
ASP A 324
TYR A 328
 None
 1.31A 2dpzA-2wgyA:
undetectable		 2dpzA-2wgyA:
13.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  71
THR A 239
GLY A 244
THR A 247
LEU A 293
 HEM  A 450 ( 4.3A)
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
HEM  A 450 (-4.4A)
 0.71A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 MET A  89
THR A 239
GLY A 244
THR A 247
LEU A 293
 HEM  A 450 (-4.3A)
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
HEM  A 450 (-4.4A)
 1.18A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 MET A  89
THR A 239
THR A 242
GLY A 244
THR A 247
 HEM  A 450 (-4.3A)
None
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
 1.02A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 139
PHE A 401
ARG A 374
THR A 369
 None
 1.05A 3ag2N-2wgyA:
undetectable
3ag2W-2wgyA:
undetectable		 3ag2N-2wgyA:
22.20
3ag2W-2wgyA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A 450 (-3.5A)
HEM  A 450 (-3.6A)
HEM  A 450 (-2.2A)
 0.50A 3e4eA-2wgyA:
27.6		 3e4eA-2wgyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A 450 (-3.5A)
HEM  A 450 (-3.6A)
HEM  A 450 (-2.2A)
 0.48A 3e4eB-2wgyA:
27.8		 3e4eB-2wgyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 108
GLN A 363
PHE A 166
VAL A 174
THR A 247
 None
None
None
None
HEM  A 450 (-3.6A)
 1.26A 3em0B-2wgyA:
undetectable		 3em0B-2wgyA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 130
LEU A 131
LEU A 143
GLU A 142
 None
 1.07A 3h5gB-2wgyA:
undetectable
3h5gC-2wgyA:
undetectable		 3h5gB-2wgyA:
6.16
3h5gC-2wgyA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.03A 3n8wA-2wgyA:
0.7		 3n8wA-2wgyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.01A 3n8zA-2wgyA:
undetectable		 3n8zA-2wgyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.04A 3rr3A-2wgyA:
undetectable		 3rr3A-2wgyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.05A 3rr3B-2wgyA:
0.5		 3rr3B-2wgyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.04A 3rr3C-2wgyA:
undetectable		 3rr3C-2wgyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.05A 3rr3D-2wgyA:
0.5		 3rr3D-2wgyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 357
MET A 251
THR A 247
PHE A 347
 SO4  A1412 ( 4.8A)
HEM  A 450 ( 3.8A)
HEM  A 450 (-3.6A)
HEM  A 450 ( 4.8A)
 1.37A 3vasB-2wgyA:
undetectable		 3vasB-2wgyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 106
HIS A 215
SER A 105
 None
 0.95A 4mjwA-2wgyA:
undetectable
4mjwB-2wgyA:
undetectable		 4mjwA-2wgyA:
21.33
4mjwB-2wgyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		3 / 3 SER A 105
ARG A 106
HIS A 215
 None
 0.92A 4mjwA-2wgyA:
undetectable
4mjwB-2wgyA:
undetectable		 4mjwA-2wgyA:
21.33
4mjwB-2wgyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.02A 4ph9A-2wgyA:
0.2		 4ph9A-2wgyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.03A 4ph9B-2wgyA:
undetectable		 4ph9B-2wgyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 380
PHE A 144
GLY A 253
LEU A 259
ARG A 266
 None
IPA  A1408 (-4.0A)
None
None
None
 1.10A 4zbqA-2wgyA:
3.2		 4zbqA-2wgyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 324
VAL A  55
LEU A 345
 None
 0.68A 5e5jB-2wgyA:
undetectable		 5e5jB-2wgyA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 7 SER A  67
ASP A  93
PRO A  94
SER A 348
 HEM  A 450 ( 4.8A)
None
None
HEM  A 450 (-3.4A)
 1.17A 5l1fC-2wgyA:
undetectable		 5l1fC-2wgyA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		5 / 6 LEU A 283
VAL A 337
THR A 338
LEU A 259
GLU A 370
 None
 1.46A 5tudD-2wgyA:
2.0		 5tudD-2wgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wgy CYTOCHROME P450 130
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 139
PHE A 401
ARG A 374
THR A 369
 None
 1.00A 5z84N-2wgyA:
undetectable
5z84W-2wgyA:
undetectable		 5z84N-2wgyA:
22.20
5z84W-2wgyA:
9.11