SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2whn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 LEU A 104
LEU A  88
LEU A  85
MET A  77
THR A  95
 None
 1.38A 1a28B-2whnA:
undetectable		 1a28B-2whnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 LEU A  78
LEU A 148
LEU A 151
LEU A  67
LEU A  91
 None
 1.22A 1zucB-2whnA:
undetectable		 1zucB-2whnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		4 / 8 TYR A 131
ALA A  68
THR A  95
LEU A 104
 None
 0.96A 2wx2B-2whnA:
undetectable		 2wx2B-2whnA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 11 PHE A  70
ILE A 103
PHE A 100
PHE A 127
LEU A 148
 None
 1.22A 3a9eB-2whnA:
undetectable		 3a9eB-2whnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 LEU A  78
LEU A 148
LEU A 151
LEU A  67
LEU A  91
 None
 1.21A 3d90B-2whnA:
undetectable		 3d90B-2whnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		4 / 8 TYR A 131
ALA A  68
THR A  95
LEU A 104
 None
 0.99A 3khmA-2whnA:
undetectable		 3khmA-2whnA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 VAL A 111
LEU A 148
LEU A  88
VAL A 135
GLY A 138
 None
 1.08A 3rr3C-2whnA:
undetectable		 3rr3C-2whnA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 VAL A 111
LEU A 148
LEU A  88
VAL A 135
GLY A 138
 None
 1.09A 3rr3D-2whnA:
undetectable		 3rr3D-2whnA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 LEU A  88
VAL A 111
MET A 115
LEU A 151
LEU A  67
 None
 1.36A 4o8fB-2whnA:
undetectable		 4o8fB-2whnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		4 / 7 VAL A 135
LEU A 121
SER A 122
GLU A 119
 None
 1.06A 4zphA-2whnA:
undetectable
4zphB-2whnA:
undetectable		 4zphA-2whnA:
14.77
4zphB-2whnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		4 / 7 LEU A 146
ASP A 149
ALA A 152
LEU A 155
 None
 0.90A 5nwvA-2whnA:
undetectable		 5nwvA-2whnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2whn PILUS ASSEMBLY
PROTEIN PILC
(Thermus
thermophilus) 		5 / 12 GLU A 112
LEU A  74
ILE A  90
ALA A  89
GLU A  92
 None
 1.12A 5v0vA-2whnA:
undetectable		 5v0vA-2whnA:
13.69