SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		4 / 8 ILE A 252
ASN A  11
ASN A 101
LEU A 141
 None
 0.93A 1dzmA-2wiaA:
undetectable		 1dzmA-2wiaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 11 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 0.91A 1t3rB-2wiaA:
undetectable		 1t3rB-2wiaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		4 / 5 SER A 215
LEU A 206
GLY A 205
ARG A 248
 None
 0.97A 2j2pA-2wiaA:
undetectable
2j2pB-2wiaA:
undetectable		 2j2pA-2wiaA:
19.71
2j2pB-2wiaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		4 / 6 ARG A 248
SER A 215
LEU A 206
GLY A 205
 None
 0.99A 2j2pA-2wiaA:
undetectable
2j2pC-2wiaA:
undetectable		 2j2pA-2wiaA:
19.71
2j2pC-2wiaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		4 / 6 ARG A 248
SER A 215
LEU A 206
GLY A 205
 None
 0.97A 2j2pD-2wiaA:
undetectable
2j2pF-2wiaA:
undetectable		 2j2pD-2wiaA:
19.71
2j2pF-2wiaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		4 / 7 ILE A 113
GLY A  84
TYR A 218
LEU A  57
 None
 0.90A 3elzA-2wiaA:
undetectable		 3elzA-2wiaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 10 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 0.95A 3em3B-2wiaA:
undetectable		 3em3B-2wiaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 LEU A   8
VAL A 116
ILE A 156
VAL A  92
ILE A  90
 None
 0.90A 3k4vC-2wiaA:
undetectable		 3k4vC-2wiaA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 1.01A 3mwsB-2wiaA:
undetectable		 3mwsB-2wiaA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 1.01A 3pwmA-2wiaA:
undetectable		 3pwmA-2wiaA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.18A 3w67C-2wiaA:
undetectable		 3w67C-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.08A 3w68A-2wiaA:
undetectable		 3w68A-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 117
 None
 1.06A 3w68B-2wiaA:
undetectable		 3w68B-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.04A 3w68D-2wiaA:
undetectable		 3w68D-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 0.90A 4dqbA-2wiaA:
undetectable		 4dqbA-2wiaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 11 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 0.97A 4dqeA-2wiaA:
undetectable		 4dqeA-2wiaA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 11 LEU A   8
VAL A 116
GLY A 155
VAL A  92
ILE A  90
 None
 0.93A 4dqhA-2wiaA:
undetectable		 4dqhA-2wiaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 10 LEU A 119
ASN A  11
ASP A  94
ALA A 125
ILE A 132
 None
 1.12A 4xj7C-2wiaA:
4.7
4xj7D-2wiaA:
4.7		 4xj7C-2wiaA:
25.51
4xj7D-2wiaA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wia FERROUS IRON
TRANSPORT PROTEIN B
(Klebsiella
pneumoniae) 		5 / 12 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.04A 5mugA-2wiaA:
undetectable		 5mugA-2wiaA:
20.44