SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 8 VAL A 205
ARG A 162
ALA A 132
GLU A 181
 None
 1.02A 1dmiA-2wimA:
undetectable
1dmiB-2wimA:
undetectable		 1dmiA-2wimA:
20.13
1dmiB-2wimA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		3 / 3 PRO A 209
ASP A 290
GLU A 289
 None
 0.83A 3v4tC-2wimA:
undetectable		 3v4tC-2wimA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		3 / 3 LYS A 260
GLU A 265
TRP A 244
 None
 1.39A 3v4tH-2wimA:
undetectable		 3v4tH-2wimA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 5 ASP A 197
THR A 116
LEU A 115
GLU A 195
 None
 1.50A 4a3pA-2wimA:
undetectable		 4a3pA-2wimA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		5 / 11 ASN A 273
ASN A 219
GLY A 276
SER A 274
GLY A 225
 None
NAG  A 951 (-1.8A)
None
None
None
 1.49A 4a6nC-2wimA:
undetectable		 4a6nC-2wimA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 6 GLU A  86
ILE A  85
ASN A  84
VAL A 107
 None
 1.04A 4ejwB-2wimA:
undetectable		 4ejwB-2wimA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 5 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.25A 4hytA-2wimA:
undetectable		 4hytA-2wimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		5 / 12 GLU A 119
VAL A 120
THR A 116
ARG A 118
SER A  33
 None
 1.44A 4k88A-2wimA:
undetectable		 4k88A-2wimA:
19.14