SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wiu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB
(Escherichia
coli) 		5 / 12 THR B  52
PHE B  57
LEU B  64
VAL B  20
ALA B  16
 None
 1.46A 1q23D-2wiuB:
undetectable
1q23E-2wiuB:
undetectable		 1q23D-2wiuB:
19.07
1q23E-2wiuB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB
(Escherichia
coli) 		3 / 3 ASP B  50
ASN B  51
THR B  41
 None
 0.65A 2pymB-2wiuB:
undetectable		 2pymB-2wiuB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB
(Escherichia
coli) 		3 / 3 ASP B  50
ASN B  51
THR B  41
 None
 0.75A 2q63B-2wiuB:
undetectable		 2q63B-2wiuB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB
(Escherichia
coli) 		4 / 4 ASN B  15
SER B  63
LEU B  64
THR B  11
 None
 1.44A 4an2A-2wiuB:
undetectable		 4an2A-2wiuB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB
(Escherichia
coli) 		4 / 6 LEU B  64
THR B  56
LEU B  66
SER B  67
 None
 0.91A 4pwjA-2wiuB:
undetectable		 4pwjA-2wiuB:
19.38