SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		4 / 8 PHE A  94
ILE A  50
LEU A  12
GLU A   9
 None
 0.88A 1eupA-2wizA:
undetectable		 1eupA-2wizA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		4 / 7 PHE A  94
GLU A  80
TYR A  82
LEU A  48
 None
 1.12A 1rmtB-2wizA:
undetectable		 1rmtB-2wizA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  13
LEU A  12
ILE A  50
ILE A  24
LEU A  48
 None
 0.92A 3gcsA-2wizA:
undetectable		 3gcsA-2wizA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		5 / 9 PHE A  94
LEU A  12
VAL A  52
LEU A  48
ILE A  50
 None
 0.94A 3tbgD-2wizA:
undetectable		 3tbgD-2wizA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  23
LEU A  48
ALA A 124
ILE A 120
ALA A  19
 None
 1.16A 5eypB-2wizA:
undetectable		 5eypB-2wizA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2wiz ARCHAEAL HJC
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  23
LEU A  48
ALA A 124
ILE A 120
ALA A  19
 None
 1.05A 5nm5B-2wizA:
undetectable		 5nm5B-2wizA:
16.78