SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		5 / 9 ILE A 152
TYR A 142
ILE A 113
ALA A 110
GLU A 109
 None
 1.27A 1mrgA-2wj9A:
undetectable		 1mrgA-2wj9A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 126
VAL A  53
TRP A  56
 None
 1.27A 1qw6A-2wj9A:
undetectable		 1qw6A-2wj9A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		5 / 11 HIS A 146
TYR A  72
PHE A  80
ILE A 113
GLU A 109
 None
 1.26A 1rnrA-2wj9A:
undetectable		 1rnrA-2wj9A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 126
VAL A  53
TRP A  56
 None
 1.23A 1vagA-2wj9A:
undetectable		 1vagA-2wj9A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 126
VAL A  53
TRP A  56
 None
 1.24A 1zviA-2wj9A:
undetectable		 1zviA-2wj9A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		5 / 11 VAL A  94
THR A  92
GLU A 148
ALA A 151
ALA A 114
 None
 1.27A 2admB-2wj9A:
undetectable		 2admB-2wj9A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 135
GLY A  41
ILE A  43
 None
 0.56A 4k50A-2wj9A:
undetectable		 4k50A-2wj9A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 135
GLY A  41
ILE A  43
 None
 0.58A 4k50I-2wj9A:
undetectable		 4k50I-2wj9A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		5 / 12 GLU A  50
ALA A 115
HIS A 135
TYR A 120
PHE A  40
 None
 1.48A 5arfA-2wj9A:
undetectable		 5arfA-2wj9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		5 / 9 ILE A 152
TYR A 142
ILE A 113
ALA A 110
GLU A 109
 None
 1.27A 5cf9B-2wj9A:
undetectable		 5cf9B-2wj9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2wj9 INTERGENIC-REGION
PROTEIN
(Escherichia
coli) 		3 / 3 THR A   9
PRO A  28
ARG A  32
 None
 0.85A 5nd7B-2wj9A:
undetectable		 5nd7B-2wj9A:
15.78