SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 11 ALA A  43
HIS A  47
ARG A  25
LEU A  64
ALA A  48
 None
NI  A1149 (-3.6A)
None
None
None
 1.28A 1mjlA-2wjaA:
undetectable
1mjlB-2wjaA:
undetectable		 1mjlA-2wjaA:
21.84
1mjlB-2wjaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		3 / 3 HIS A  67
ILE A  54
LEU A  62
 None
 0.50A 2kceA-2wjaA:
undetectable		 2kceA-2wjaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 12 ALA A  77
SER A  74
ILE A  97
GLY A  40
PHE A  72
 None
 1.18A 3nrrA-2wjaA:
undetectable		 3nrrA-2wjaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 12 ALA A  77
SER A  74
ILE A  97
GLY A  40
PHE A  72
 None
 1.20A 3nrrB-2wjaA:
undetectable		 3nrrB-2wjaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 12 GLY A  42
ASP A 119
VAL A 131
LEU A 135
SER A  89
 None
PO4  A1148 (-3.3A)
None
None
None
 1.16A 5vooB-2wjaA:
undetectable		 5vooB-2wjaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 12 GLY A  42
ASP A 119
VAL A 131
LEU A 135
SER A  89
 None
PO4  A1148 (-3.3A)
None
None
None
 1.20A 5vooC-2wjaA:
undetectable		 5vooC-2wjaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		5 / 12 GLY A  42
ASP A 119
VAL A 131
LEU A 135
SER A  89
 None
PO4  A1148 (-3.3A)
None
None
None
 1.17A 5vooE-2wjaA:
undetectable		 5vooE-2wjaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		4 / 4 HIS A  67
LEU A  62
TYR A 132
GLY A  23
 None
 1.11A 6n91A-2wjaA:
undetectable		 6n91A-2wjaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 2wja PUTATIVE ACID
PHOSPHATASE WZB
(Escherichia
coli) 		4 / 4 HIS A  67
LEU A  62
TYR A 132
GLY A  23
 None
 1.13A 6n91B-2wjaA:
undetectable		 6n91B-2wjaA:
21.47