SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 PHE A2421
VAL A2360
VAL A2483
SER A2406
LEU A2423
 None
 1.00A 1fm4A-2wjsA:
undetectable		 1fm4A-2wjsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 GLY A2455
ASP A2383
GLY A2403
THR A2447
 CA  A5002 (-3.5A)
CA  A5003 ( 2.7A)
None
None
 0.95A 1hxbB-2wjsA:
undetectable		 1hxbB-2wjsA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 GLY A2341
GLU A2342
GLY A2343
GLY A2512
ASN A2414
 None
 0.96A 1n2xB-2wjsA:
undetectable		 1n2xB-2wjsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 ILE A2635
VAL A2633
PHE A2631
LEU A2595
ILE A2546
 None
 1.28A 1uduA-2wjsA:
undetectable		 1uduA-2wjsA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 GLY A2660
PHE A2657
PHE A2692
VAL A2680
VAL A2525
 None
 1.12A 1ukbA-2wjsA:
undetectable		 1ukbA-2wjsA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 THR A2422
LEU A2423
ILE A2432
VAL A2445
PHE A2362
 None
 1.25A 1wsvA-2wjsA:
undetectable		 1wsvA-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 THR A2422
LEU A2423
ILE A2432
VAL A2445
PHE A2362
 None
 1.27A 1wsvB-2wjsA:
undetectable		 1wsvB-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 THR A2422
LEU A2423
ILE A2432
VAL A2445
TYR A2398
 None
 1.35A 1wsvB-2wjsA:
undetectable		 1wsvB-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 LEU A2423
VAL A2360
SER A2358
LEU A2372
LEU A2492
 None
 1.23A 2hc4A-2wjsA:
undetectable		 2hc4A-2wjsA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		3 / 3 LEU A2389
TYR A2488
GLY A2341
 None
 0.64A 2ocuA-2wjsA:
undetectable		 2ocuA-2wjsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 LEU A2423
VAL A2360
SER A2358
LEU A2372
LEU A2492
 None
 1.25A 2zlcA-2wjsA:
undetectable		 2zlcA-2wjsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 GLY A2455
ASP A2383
GLY A2403
THR A2447
 CA  A5002 (-3.5A)
CA  A5003 ( 2.7A)
None
None
 0.96A 3k4vC-2wjsA:
undetectable		 3k4vC-2wjsA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		6 / 12 GLY A2341
GLY A2467
LEU A2469
SER A2386
ALA A2371
ASN A2484
 None
 1.28A 3kkzB-2wjsA:
undetectable		 3kkzB-2wjsA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 6 VAL A2170
MET A2299
PHE A2295
VAL A2174
 None
 1.15A 3soaA-2wjsA:
undetectable		 3soaA-2wjsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ILE A2584
VAL A2593
TYR A2582
ILE A2540
ILE A2546
 None
 1.31A 3vrjA-2wjsA:
2.4
3vrjC-2wjsA:
undetectable		 3vrjA-2wjsA:
18.94
3vrjC-2wjsA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ILE A2673
LEU A2656
VAL A2525
ILE A2584
LEU A2548
 None
 0.98A 3w67B-2wjsA:
undetectable		 3w67B-2wjsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ILE A2673
LEU A2656
VAL A2525
ILE A2584
LEU A2548
 None
 0.98A 3w68B-2wjsA:
undetectable		 3w68B-2wjsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 5 HIS A2257
LEU A2203
LEU A2191
ASP A2205
 NAG  A4001 (-3.5A)
None
None
None
 1.26A 4aqlA-2wjsA:
undetectable		 4aqlA-2wjsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 8 THR A2552
LEU A2591
LEU A2586
VAL A2680
 None
 0.85A 4c9nA-2wjsA:
undetectable		 4c9nA-2wjsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 SER A2201
LEU A2203
ALA A2289
THR A2294
ALA A2192
 None
 1.16A 4x1kA-2wjsA:
undetectable
4x1kB-2wjsA:
undetectable		 4x1kA-2wjsA:
20.61
4x1kB-2wjsA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 ASN A2431
SER A2448
ALA A2446
VAL A2445
 NAG  A4003 (-1.9A)
None
None
None
 1.29A 4x1kC-2wjsA:
undetectable		 4x1kC-2wjsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 GLY A2468
TYR A2465
ALA A2377
LEU A2469
LEU A2372
 None
 1.01A 4xj7A-2wjsA:
undetectable
4xj7B-2wjsA:
undetectable		 4xj7A-2wjsA:
18.40
4xj7B-2wjsA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 PHE A2527
ASP A2702
GLY A2531
SER A2526
 None
 1.17A 4xp9C-2wjsA:
undetectable		 4xp9C-2wjsA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
 None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
 1.25A 5hfjA-2wjsA:
undetectable		 5hfjA-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
 None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
 1.31A 5hfjE-2wjsA:
undetectable		 5hfjE-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
 None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
 1.28A 5hfjH-2wjsA:
undetectable		 5hfjH-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 6 GLY A2589
GLU A2555
PHE A2614
ILE A2559
 None
 0.74A 5kmfA-2wjsA:
undetectable
5kmfC-2wjsA:
undetectable		 5kmfA-2wjsA:
17.02
5kmfC-2wjsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wjs LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 GLN A2429
THR A2447
LEU A2456
LEU A2400
 None
None
None
CA  A5002 ( 4.7A)
 1.17A 5m5kB-2wjsA:
undetectable		 5m5kB-2wjsA:
23.34