SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 LEU A 232
VAL A 191
GLU A 178
LEU A 170
VAL A 135
 None
 1.15A 1cqpA-2wjvA:
undetectable
1cqpB-2wjvA:
undetectable		 1cqpA-2wjvA:
15.03
1cqpB-2wjvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ILE A 362
ALA A 343
PHE A 409
GLN A 410
ASN A 328
 None
 1.13A 1dhfA-2wjvA:
undetectable		 1dhfA-2wjvA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 HIS A 535
ILE A 534
ALA A 526
VAL A 519
 None
 1.00A 1hk1A-2wjvA:
2.0		 1hk1A-2wjvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 TRP A 739
TYR A 868
LEU A 708
 None
 1.11A 1kxhA-2wjvA:
undetectable		 1kxhA-2wjvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 LEU A 489
LEU A 684
LEU A 691
GLY A 692
 None
 0.84A 1n13D-2wjvA:
undetectable
1n13E-2wjvA:
undetectable		 1n13D-2wjvA:
9.11
1n13E-2wjvA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 CYH A 209
ARG D1128
CYH A 186
 ZN  A   3 (-2.1A)
None
ZN  A   3 (-2.3A)
 1.25A 1p9gA-2wjvA:
undetectable		 1p9gA-2wjvA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 496
VAL A 660
GLY A 661
ILE A 696
 None
 0.72A 2a1mB-2wjvA:
undetectable		 2a1mB-2wjvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 4 ILE A 565
ASP A 582
LEU A 577
ARG A 624
 None
None
None
SO4  A 999 (-2.9A)
 1.25A 2a7qA-2wjvA:
undetectable		 2a7qA-2wjvA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 PHE A 558
LEU A 559
VAL A 541
VAL A 527
LEU A 518
 None
 1.37A 2hc4A-2wjvA:
undetectable		 2hc4A-2wjvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 LEU A 659
SER A 436
PHE A 430
ASP A 433
 None
 1.25A 2vn1B-2wjvA:
undetectable		 2vn1B-2wjvA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 GLU A 394
GLN A 358
ARG A 549
 None
None
SO4  A 989 (-4.2A)
 1.00A 2w3bB-2wjvA:
undetectable		 2w3bB-2wjvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 HIS A 847
ILE A 850
PHE A 852
TYR A 796
 SO4  A 991 (-4.7A)
SO4  A 997 (-4.4A)
SO4  A 996 (-4.8A)
SO4  A 997 (-4.7A)
 1.46A 3ccfB-2wjvA:
3.3		 3ccfB-2wjvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ALA A 770
ILE A 823
MET A 807
ILE A 790
ILE A 776
 None
 1.17A 3clbB-2wjvA:
undetectable		 3clbB-2wjvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.37A 3dqtA-2wjvA:
undetectable
3dqtB-2wjvA:
4.0		 3dqtA-2wjvA:
20.08
3dqtB-2wjvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 ARG A 624
ALA A 610
ASP A 611
ILE A 534
ILE A 613
 SO4  A 999 (-2.9A)
None
None
None
None
 0.99A 3ekwA-2wjvA:
undetectable		 3ekwA-2wjvA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ILE A 793
PHE A 852
LEU A 859
ILE A 872
LEU A 888
 None
SO4  A 996 (-4.8A)
None
None
None
 1.18A 3k2hB-2wjvA:
undetectable		 3k2hB-2wjvA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 GLN A 701
GLY A 495
PHE A 711
GLU A 833
ASN A 860
 None
SO4  A 990 ( 4.9A)
None
None
None
 0.99A 3kkzB-2wjvA:
2.5		 3kkzB-2wjvA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.92A 3ln1A-2wjvA:
undetectable		 3ln1A-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.92A 3ln1B-2wjvA:
undetectable		 3ln1B-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.92A 3ln1C-2wjvA:
undetectable		 3ln1C-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.91A 3ln1D-2wjvA:
undetectable		 3ln1D-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 SER A 240
VAL A 243
TRP A 241
PHE A 196
 None
 1.35A 3n5tA-2wjvA:
undetectable
3n5tB-2wjvA:
undetectable		 3n5tA-2wjvA:
20.37
3n5tB-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 ARG A 624
ALA A 610
ASP A 611
ILE A 534
ILE A 613
 SO4  A 999 (-2.9A)
None
None
None
None
 1.02A 3ndwB-2wjvA:
undetectable		 3ndwB-2wjvA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 ALA A 824
ILE A 793
ARG A 832
GLY A 791
 None
None
SO4  A 993 (-3.4A)
None
 0.87A 3v4tH-2wjvA:
undetectable		 3v4tH-2wjvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.36A 4k5jA-2wjvA:
undetectable
4k5jB-2wjvA:
undetectable		 4k5jA-2wjvA:
20.37
4k5jB-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ILE A 257
GLY A 147
GLY A 149
ILE A 128
ALA A 254
 None
 1.03A 4kicB-2wjvA:
3.0		 4kicB-2wjvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 LEU A 320
ASP A 317
TYR A 316
 None
 0.59A 4qc6B-2wjvA:
undetectable		 4qc6B-2wjvA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 TRP A 739
GLY A 784
PHE A 836
ILE A 790
 None
 1.06A 4qogA-2wjvA:
undetectable
4qogB-2wjvA:
undetectable		 4qogA-2wjvA:
15.04
4qogB-2wjvA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 LEU A 666
ASP A 662
GLU A 637
ILE A 793
 None
 1.09A 4xi3C-2wjvA:
undetectable		 4xi3C-2wjvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 ALA A 299
TYR A 296
PRO A 644
 None
 0.70A 4zdyA-2wjvA:
undetectable		 4zdyA-2wjvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.35A 5adlA-2wjvA:
undetectable
5adlB-2wjvA:
3.3		 5adlA-2wjvA:
20.37
5adlB-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.33A 5fj3A-2wjvA:
undetectable
5fj3B-2wjvA:
3.8		 5fj3A-2wjvA:
20.37
5fj3B-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.87A 5jw1A-2wjvA:
undetectable		 5jw1A-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 518
LEU A 509
VAL A 650
GLY A 653
ALA A 654
 None
 1.09A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.89A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 ARG A 703
PRO A 494
ASN A 860
 SO4  A 990 (-2.9A)
SO4  A 990 (-3.8A)
None
 0.92A 5jwaA-2wjvA:
undetectable
5jwaH-2wjvA:
undetectable		 5jwaA-2wjvA:
22.44
5jwaH-2wjvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 5 SER A 438
VAL A 437
GLY A 653
ALA A 654
 None
 0.98A 5k50A-2wjvA:
2.6		 5k50A-2wjvA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
SO4  A 990 (-3.8A)
None
 0.77A 5l8dB-2wjvA:
undetectable		 5l8dB-2wjvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 804
GLU A 797
GLY A 798
ILE A 757
ARG A 843
 None
None
None
None
SO4  A 991 (-3.0A)
 1.44A 5lsaA-2wjvA:
3.9		 5lsaA-2wjvA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
SO4  A 990 (-3.8A)
None
 0.77A 5mwuB-2wjvA:
undetectable		 5mwuB-2wjvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.33A 5vv7A-2wjvA:
undetectable
5vv7B-2wjvA:
3.8		 5vv7A-2wjvA:
20.37
5vv7B-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.35A 5vvnA-2wjvA:
undetectable
5vvnB-2wjvA:
undetectable		 5vvnA-2wjvA:
20.37
5vvnB-2wjvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 SER A 240
VAL A 243
TRP A 241
PHE A 196
 None
 1.36A 6av6A-2wjvA:
undetectable
6av6B-2wjvA:
undetectable		 6av6A-2wjvA:
7.53
6av6B-2wjvA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 TRP A 241
PHE A 196
SER A 240
VAL A 243
 None
 1.39A 6av6C-2wjvA:
undetectable
6av6D-2wjvA:
undetectable		 6av6C-2wjvA:
7.53
6av6D-2wjvA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 SER A 240
VAL A 243
TRP A 241
PHE A 196
 None
 1.37A 6av7A-2wjvA:
0.0
6av7B-2wjvA:
undetectable		 6av7A-2wjvA:
7.53
6av7B-2wjvA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 LEU A 194
ASN A 138
LEU A 160
 None
 0.68A 6exiD-2wjvA:
2.2		 6exiD-2wjvA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 GLU A 718
ARG A 697
VAL A 689
PRO A 695
 None
 1.39A 6fgdA-2wjvA:
undetectable		 6fgdA-2wjvA:
20.78