SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		4 / 8 LEU A  71
ARG A  52
THR A  29
ALA A  62
 None
 0.90A 1fiqC-2wk1A:
undetectable		 1fiqC-2wk1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		6 / 11 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
ILE A  23
 None
None
SAH  A 301 (-4.1A)
None
None
None
 1.15A 1n49B-2wk1A:
undetectable		 1n49B-2wk1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		6 / 11 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
ILE A  23
 None
None
SAH  A 301 (-4.1A)
None
None
None
 1.16A 1n49C-2wk1A:
undetectable		 1n49C-2wk1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 9 ILE A 221
VAL A 192
GLU A  92
LEU A  71
ILE A  74
 None
None
SAH  A 301 (-2.9A)
None
None
 1.06A 1nb9A-2wk1A:
undetectable		 1nb9A-2wk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		3 / 3 GLU A  92
THR A  93
LEU A 190
 SAH  A 301 (-2.9A)
None
None
 0.62A 1v8bC-2wk1A:
4.2		 1v8bC-2wk1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		4 / 6 ARG A  52
THR A  29
VAL A  30
ALA A  62
 None
 0.98A 2e1qA-2wk1A:
undetectable		 2e1qA-2wk1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.85A 2hs1B-2wk1A:
undetectable		 2hs1B-2wk1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		4 / 8 LEU A  71
ARG A  52
THR A  29
ALA A  62
 None
 0.97A 3ax9A-2wk1A:
undetectable		 3ax9A-2wk1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.89A 3d1xB-2wk1A:
undetectable		 3d1xB-2wk1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		3 / 3 GLY A  98
TRP A  96
VAL A 152
 None
 0.64A 3n62B-2wk1A:
undetectable		 3n62B-2wk1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		3 / 3 GLY A  98
TRP A  96
VAL A 152
 None
 0.67A 3n65B-2wk1A:
undetectable		 3n65B-2wk1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		3 / 3 GLY A  98
TRP A  96
VAL A 152
 None
 0.66A 3n66B-2wk1A:
undetectable		 3n66B-2wk1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.88A 3nduD-2wk1A:
undetectable		 3nduD-2wk1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 LEU A 166
TYR A 164
GLY A 106
ALA A  27
HIS A  63
 None
 1.22A 3ou7C-2wk1A:
8.8		 3ou7C-2wk1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 ASP A  57
ASP A 198
GLY A 197
ASP A 254
ASP A 196
 None
SAH  A 301 (-4.1A)
EDO  A 551 ( 3.7A)
None
SAH  A 301 ( 3.5A)
 1.11A 3prsA-2wk1A:
undetectable		 3prsA-2wk1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.90A 3pwrB-2wk1A:
undetectable		 3pwrB-2wk1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		4 / 5 THR A 206
THR A 203
SER A 202
PHE A 178
 None
EDO  A 551 (-3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.4A)
 1.05A 3snfA-2wk1A:
undetectable		 3snfA-2wk1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 HIS A 144
LEU A 143
GLY A 126
ALA A 121
LEU A 182
 SO4  A 401 (-4.0A)
None
SAH  A 301 (-3.0A)
None
None
 1.13A 3tm4A-2wk1A:
11.9		 3tm4A-2wk1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 HIS A 144
LEU A 143
GLY A 126
ALA A 121
LEU A 182
 SO4  A 401 (-4.0A)
None
SAH  A 301 (-3.0A)
None
None
 1.14A 3tm4B-2wk1A:
12.0		 3tm4B-2wk1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		4 / 5 ILE A 127
LEU A 150
ASP A 196
VAL A 157
 SAH  A 301 ( 4.6A)
None
SAH  A 301 ( 3.5A)
None
 0.84A 4nkxB-2wk1A:
undetectable		 4nkxB-2wk1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A 126
GLY A 197
ASP A 196
ILE A  66
ASP A 122
 SAH  A 301 (-3.0A)
EDO  A 551 ( 3.7A)
SAH  A 301 ( 3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-2.7A)
 1.15A 4rtsA-2wk1A:
undetectable		 4rtsA-2wk1A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		3 / 3 GLY A  98
TRP A  96
VAL A 152
 None
 0.66A 5vuoB-2wk1A:
undetectable		 5vuoB-2wk1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 9 VAL A 149
GLY A  98
VAL A 157
GLU A 156
GLY A  99
 None
 1.39A 5zniA-2wk1A:
undetectable		 5zniA-2wk1A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.96A 6dj1B-2wk1A:
undetectable		 6dj1B-2wk1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 2wk1 NOVP
(Actinoalloteichu
s
cyanogriseus) 		5 / 12 GLY A  28
ALA A  27
ILE A  66
GLY A  99
ILE A 102
 None
None
SAH  A 301 (-4.1A)
None
None
 0.95A 6dj2B-2wk1A:
undetectable		 6dj2B-2wk1A:
14.81