SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 ASP A 391
ARG A 446
ILE A 476
 NGT  A1565 (-2.9A)
SN5  A1566 ( 3.5A)
SN5  A1564 (-3.5A)
 0.87A 1a4gB-2wk2A:
undetectable		 1a4gB-2wk2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 9 TYR A 163
PHE A 191
GLY A 274
ASP A 313
ASP A 391
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 3.5A)
 0.95A 1e9lA-2wk2A:
42.4		 1e9lA-2wk2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 9 TYR A 163
PHE A 191
GLY A 274
ASP A 313
MET A 388
TYR A 390
ASP A 391
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
 0.78A 1e9lA-2wk2A:
42.4		 1e9lA-2wk2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 6 PRO A 317
ASP A 313
ASP A 311
TYR A 335
 None
NGT  A1565 (-3.4A)
None
None
 1.20A 1hpkA-2wk2A:
undetectable		 1hpkA-2wk2A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 7 ILE A 548
GLY A 546
ASN A 183
ASN A 149
 None
 0.95A 1oniG-2wk2A:
undetectable
1oniI-2wk2A:
undetectable		 1oniG-2wk2A:
15.30
1oniI-2wk2A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 PHE A 307
ALA A 233
LEU A 266
GLY A 251
LEU A 259
 None
 1.23A 1qabF-2wk2A:
undetectable		 1qabF-2wk2A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 11 TYR A 163
PHE A 191
GLY A 274
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.76A 2a3aA-2wk2A:
13.3		 2a3aA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		9 / 11 TYR A 163
PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.38A 2a3aA-2wk2A:
13.3		 2a3aA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 11 TYR A 163
PHE A 191
GLY A 274
TRP A 275
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 (-3.3A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.56A 2a3aA-2wk2A:
13.3		 2a3aA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 ASP A 391
PHE A 396
ARG A 446
 NGT  A1565 (-2.9A)
SN5  A1567 ( 4.1A)
SN5  A1566 ( 3.5A)
 0.47A 2a3aA-2wk2A:
13.3		 2a3aA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 9 PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.39A 2a3aB-2wk2A:
43.5		 2a3aB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 11 TYR A 163
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.86A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 11 TYR A 163
PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.73A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 11 TYR A 163
PHE A 191
GLY A 274
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.39A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 10 PHE A 191
ASP A 313
GLU A 315
MET A 388
TYR A 390
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 1.02A 2a3bB-2wk2A:
43.5		 2a3bB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 10 PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.86A 2a3bB-2wk2A:
43.5		 2a3bB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 10 PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.71A 2a3bB-2wk2A:
43.5		 2a3bB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 10 PHE A 191
GLY A 274
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.32A 2a3bB-2wk2A:
43.5		 2a3bB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 12 TYR A 163
TRP A 167
PHE A 191
ASP A 313
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 1.01A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 12 TYR A 163
TRP A 167
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.84A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 12 TYR A 163
TRP A 167
PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.74A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		9 / 12 TYR A 163
TRP A 167
PHE A 191
GLY A 274
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.40A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 12 TRP A 167
PHE A 191
ASP A 313
GLU A 315
MET A 388
TYR A 390
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 1.01A 2a3cB-2wk2A:
43.5		 2a3cB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 12 TRP A 167
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.83A 2a3cB-2wk2A:
43.5		 2a3cB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 12 TRP A 167
PHE A 191
GLY A 274
THR A 276
GLU A 315
MET A 388
TYR A 390
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1563 ( 3.3A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.72A 2a3cB-2wk2A:
43.5		 2a3cB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		9 / 12 TRP A 167
PHE A 191
GLY A 274
THR A 276
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1563 ( 3.3A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.40A 2a3cB-2wk2A:
43.5		 2a3cB-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 5 PRO A 280
PRO A 193
ILE A 192
GLY A 273
 None
 1.15A 2jkjD-2wk2A:
undetectable		 2jkjD-2wk2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 5 PRO A 280
PRO A 193
ILE A 192
GLY A 273
 None
 1.15A 2jkjF-2wk2A:
undetectable		 2jkjF-2wk2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 8 ILE A 482
PHE A 460
GLY A 447
ILE A 476
 None
None
None
SN5  A1564 (-3.5A)
 0.96A 2qwxA-2wk2A:
undetectable
2qwxB-2wk2A:
undetectable		 2qwxA-2wk2A:
18.75
2qwxB-2wk2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 9 TYR A 163
PHE A 191
GLY A 274
ASP A 313
GLU A 315
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.45A 2uy4A-2wk2A:
18.4		 2uy4A-2wk2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 4 VAL A 528
TYR A 527
VAL A 424
SER A 389
 None
 1.25A 2x45B-2wk2A:
0.0		 2x45B-2wk2A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 6 LEU A 235
ILE A 228
ILE A 312
LEU A 188
 None
 0.92A 2xkwB-2wk2A:
undetectable		 2xkwB-2wk2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 6 LEU A 235
ILE A 228
ILE A 312
LEU A 269
 None
 0.91A 2xkwB-2wk2A:
undetectable		 2xkwB-2wk2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 11 TYR A 163
PHE A 191
GLY A 274
ASP A 313
GLU A 315
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.72A 2xtkA-2wk2A:
19.7		 2xtkA-2wk2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 10 TYR A 163
PHE A 191
GLY A 274
ASP A 313
GLU A 315
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.55A 2xtkB-2wk2A:
19.9		 2xtkB-2wk2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 10 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.32A 2y6rA-2wk2A:
undetectable		 2y6rA-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 GLN A 532
GLY A 534
GLY A 435
LEU A 556
TYR A 527
 None
 1.16A 2zw9B-2wk2A:
undetectable		 2zw9B-2wk2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 PHE A 224
PHE A 300
ILE A 200
ASP A 202
PHE A 211
 None
 1.32A 2zznB-2wk2A:
undetectable		 2zznB-2wk2A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARQ_A_DM5A606_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 6 TRP A 275
LYS A 369
ASP A 391
TYR A 418
ARG A 446
 SN5  A1566 (-3.3A)
SN5  A1567 (-3.2A)
NGT  A1565 (-2.9A)
SN5  A1567 (-2.9A)
SN5  A1566 ( 3.5A)
 0.58A 3arqA-2wk2A:
56.1		 3arqA-2wk2A:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARR_A_PNXA606_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 7 TRP A 275
GLY A 366
LYS A 369
ASP A 391
TYR A 418
ARG A 446
 SN5  A1566 (-3.3A)
SN5  A1567 ( 4.5A)
SN5  A1567 (-3.2A)
NGT  A1565 (-2.9A)
SN5  A1567 (-2.9A)
SN5  A1566 ( 3.5A)
 0.63A 3arrA-2wk2A:
57.3		 3arrA-2wk2A:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARR_A_PNXA607_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 7 TRP A 167
SER A 210
HIS A 229
THR A 276
LEU A 277
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1563 (-3.6A)
SN5  A1563 ( 4.7A)
SN5  A1563 ( 3.3A)
None
NGT  A1565 ( 3.5A)
 0.69A 3arrA-2wk2A:
57.3		 3arrA-2wk2A:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA606_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 7 PHE A 316
GLY A 366
LYS A 369
ASP A 391
TYR A 418
ARG A 446
 None
SN5  A1567 ( 4.5A)
SN5  A1567 (-3.2A)
NGT  A1565 (-2.9A)
SN5  A1567 (-2.9A)
SN5  A1566 ( 3.5A)
 0.55A 3aruA-2wk2A:
33.2		 3aruA-2wk2A:
51.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA607_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		6 / 8 THR A 276
GLU A 315
PHE A 316
GLY A 321
ALA A 322
GLU A 473
 SN5  A1563 ( 3.3A)
SN5  A1566 ( 2.9A)
None
None
None
SN5  A1564 ( 3.6A)
 0.40A 3aruA-2wk2A:
33.2		 3aruA-2wk2A:
51.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA608_1
(CHITINASE A)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 6 TRP A 167
SER A 210
ALA A 213
HIS A 229
ASP A 230
 SN5  A1563 ( 4.0A)
SN5  A1563 (-3.6A)
None
SN5  A1563 ( 4.7A)
None
 0.38A 3aruA-2wk2A:
33.2		 3aruA-2wk2A:
51.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 8 GLN A 261
VAL A 129
HIS A 137
ARG A 107
 None
 1.25A 3b9lA-2wk2A:
undetectable		 3b9lA-2wk2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		7 / 11 TYR A 163
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.87A 3g6mA-2wk2A:
43.9		 3g6mA-2wk2A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		10 / 11 TYR A 163
PHE A 191
GLY A 274
TRP A 275
GLU A 315
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 (-3.3A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.59A 3g6mA-2wk2A:
43.9		 3g6mA-2wk2A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 GLY A 453
VAL A 468
GLY A 450
ALA A 395
ASP A 397
 None
 1.01A 3keeC-2wk2A:
undetectable		 3keeC-2wk2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 4 GLY A 546
GLU A 147
ASP A 542
ASP A 547
 None
 1.09A 3mb5A-2wk2A:
undetectable		 3mb5A-2wk2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 7 ILE A 192
PHE A 306
MET A 257
GLY A 254
 None
 1.11A 3sj0X-2wk2A:
undetectable		 3sj0X-2wk2A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 7 LEU A 204
ASN A 201
ILE A 272
THR A 276
 None
None
None
SN5  A1563 ( 3.3A)
 0.82A 3spkB-2wk2A:
undetectable		 3spkB-2wk2A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 THR A 303
PHE A 300
LEU A  53
VAL A  43
ALA A 234
 None
 0.96A 3u9fD-2wk2A:
undetectable
3u9fE-2wk2A:
undetectable		 3u9fD-2wk2A:
15.17
3u9fE-2wk2A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 10 THR A 303
PHE A 300
PHE A 306
LEU A  53
VAL A  43
 None
 1.08A 3u9fE-2wk2A:
undetectable		 3u9fE-2wk2A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 4 SER A 555
ASP A 517
ASP A 496
ALA A 523
 None
 1.33A 3uj6A-2wk2A:
undetectable		 3uj6A-2wk2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.23A 3v3oB-2wk2A:
undetectable		 3v3oB-2wk2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 10 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.27A 3v3oD-2wk2A:
0.0		 3v3oD-2wk2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 SER A 136
GLY A 135
GLN A 261
 None
 0.63A 3v4tH-2wk2A:
undetectable		 3v4tH-2wk2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		11 / 11 PHE A 191
GLY A 274
TRP A 275
ASP A 313
GLU A 315
MET A 388
TYR A 390
ASP A 391
TYR A 444
ARG A 446
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 (-3.3A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
SN5  A1566 ( 3.5A)
NGT  A1565 ( 3.5A)
 0.49A 3wqvA-2wk2A:
42.8		 3wqvA-2wk2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		11 / 11 PHE A 191
GLY A 274
TRP A 275
ASP A 313
GLU A 315
MET A 388
TYR A 390
ASP A 391
TYR A 444
ARG A 446
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 (-3.3A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
SN5  A1566 ( 3.5A)
NGT  A1565 ( 3.5A)
 0.51A 3wqwA-2wk2A:
42.9		 3wqwA-2wk2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.20A 4a6nA-2wk2A:
undetectable		 4a6nA-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.20A 4a6nB-2wk2A:
undetectable		 4a6nB-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.20A 4a6nC-2wk2A:
0.0		 4a6nC-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 10 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.33A 4a99A-2wk2A:
undetectable		 4a99A-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.30A 4a99B-2wk2A:
undetectable		 4a99B-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.31A 4a99C-2wk2A:
undetectable		 4a99C-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 11 PHE A 316
ASN A 323
GLY A 319
GLY A 273
MET A 388
 None
None
None
None
NGT  A1565 (-3.7A)
 1.32A 4a99D-2wk2A:
undetectable		 4a99D-2wk2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 6 PHE A 293
ILE A 192
PRO A 193
PHE A 281
 None
 1.11A 4fgkA-2wk2A:
undetectable		 4fgkA-2wk2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 GLY A 447
LEU A 401
ILE A 513
ASN A 474
VAL A 468
 None
 1.08A 4fr0A-2wk2A:
undetectable		 4fr0A-2wk2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 10 GLY A 470
ARG A 172
ALA A 543
VAL A 477
PRO A 467
 None
SN5  A1563 ( 4.2A)
None
None
None
 1.41A 4j4vB-2wk2A:
0.0		 4j4vB-2wk2A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 ASP A 368
TRP A 275
SER A 364
 SN5  A1567 ( 4.8A)
SN5  A1566 (-3.3A)
SN5  A1567 ( 4.4A)
 0.99A 4lrhB-2wk2A:
undetectable		 4lrhB-2wk2A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 ASP A 368
TRP A 275
SER A 364
 SN5  A1567 ( 4.8A)
SN5  A1566 (-3.3A)
SN5  A1567 ( 4.4A)
 0.97A 4lrhF-2wk2A:
undetectable		 4lrhF-2wk2A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 ALA A 442
GLY A 525
SER A 538
GLY A 440
ASP A 517
 None
 1.00A 4mm8A-2wk2A:
undetectable		 4mm8A-2wk2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 8 ILE A 194
SER A 203
LEU A 326
ILE A 200
 None
 0.97A 4xtaB-2wk2A:
undetectable		 4xtaB-2wk2A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA602_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 TRP A 275
GLU A 315
ASP A 391
 SN5  A1566 (-3.3A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-2.9A)
 0.18A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA603_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		8 / 8 PHE A 191
GLY A 274
TRP A 275
GLU A 315
TYR A 390
ASP A 391
ARG A 446
TRP A 539
 SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 (-3.3A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
SN5  A1566 ( 3.5A)
NGT  A1565 ( 3.5A)
 0.25A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA604_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 4 TRP A 167
TRP A 275
THR A 276
LEU A 277
 SN5  A1563 ( 4.0A)
SN5  A1566 (-3.3A)
SN5  A1563 ( 3.3A)
None
 0.30A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA605_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 TRP A 167
ILE A 207
SER A 210
 SN5  A1563 ( 4.0A)
SN5  A1563 ( 4.0A)
SN5  A1563 (-3.6A)
 0.68A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA605_1
(CHITINASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		3 / 3 TRP A 314
ILE A 312
SER A 361
 None
 0.92A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 ALA A 464
PRO A 459
HIS A 403
GLY A 402
THR A 416
 None
 1.19A 5hfjB-2wk2A:
undetectable		 5hfjB-2wk2A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 THR A  97
ALA A  98
SER A  94
GLY A  93
THR A  73
 None
 1.20A 5lf7V-2wk2A:
undetectable
5lf7b-2wk2A:
undetectable		 5lf7V-2wk2A:
18.57
5lf7b-2wk2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 8 THR A 494
PRO A 502
ASP A 547
GLY A 445
 None
 0.97A 5nzyA-2wk2A:
1.4		 5nzyA-2wk2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		4 / 7 ILE A 312
LEU A 342
MET A 345
LEU A 346
 None
 0.99A 5u4sA-2wk2A:
2.5		 5u4sA-2wk2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2wk2 CHITINASE A
(Serratia
marcescens) 		5 / 12 LEU A 549
GLY A 546
ASN A 545
TYR A 152
ALA A 554
 None
 1.19A 5x66A-2wk2A:
undetectable
5x66B-2wk2A:
undetectable		 5x66A-2wk2A:
20.83
5x66B-2wk2A:
20.83