SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 7 GLY A 256
ILE A 260
TYR A 328
GLY A 360
None
0.75A 11gsB-2wknA:
undetectable
11gsB-2wknA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 6 PHE A 384
VAL A 144
GLY A 143
LEU A 352
None
0.62A 1e7bB-2wknA:
undetectable
1e7bB-2wknA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 7 GLN A  19
LEU A 158
SER A 247
SER A  73
None
1.16A 1ig3A-2wknA:
3.0
1ig3B-2wknA:
2.8
1ig3A-2wknA:
21.00
1ig3B-2wknA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 6 CYH A 157
PRO A 159
LEU A 158
HIS A  21
None
1.48A 1oafA-2wknA:
0.0
1oafA-2wknA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 7 ILE A 260
GLY A 354
PHE A 107
ASN A 105
None
0.91A 1oniG-2wknA:
1.5
1oniI-2wknA:
undetectable
1oniG-2wknA:
15.93
1oniI-2wknA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 GLY A 106
GLY A 264
ILE A  52
ASP A  60
SER A 127
None
ZN  A 412 ( 4.6A)
None
None
None
1.14A 1ri4A-2wknA:
undetectable
1ri4A-2wknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 10 TYR A 240
LEU A 158
GLY A 245
TRP A  24
GLY A 156
None
1.30A 1ruaH-2wknA:
undetectable
1ruaL-2wknA:
undetectable
1ruaH-2wknA:
21.86
1ruaL-2wknA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 ALA A 244
TRP A  24
PHE A 237
LEU A  87
VAL A 272
None
1.12A 1xdkA-2wknA:
undetectable
1xdkA-2wknA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 4 GLY A 245
SER A 247
ILE A  28
HIS A  21
None
1.28A 1yajJ-2wknA:
undetectable
1yajJ-2wknA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 ARG A 139
GLU A  59
SER A 138
None
0.86A 2xkkA-2wknA:
undetectable
2xkkC-2wknA:
undetectable
2xkkA-2wknA:
20.10
2xkkC-2wknA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 5 ILE A 226
PHE A 237
PRO A 217
VAL A  32
None
1.17A 2ygnA-2wknA:
undetectable
2ygnA-2wknA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 5 PRO A  36
VAL A  78
GLY A 282
LYS A 285
None
1.12A 3elzB-2wknA:
undetectable
3elzB-2wknA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 ALA A 186
PRO A 183
GLY A 113
ASP A 178
ARG A 181
None
1.08A 3m6vA-2wknA:
undetectable
3m6vA-2wknA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 ALA A 186
PRO A 183
GLY A 113
ASP A 178
ARG A 181
None
1.09A 3m6vB-2wknA:
undetectable
3m6vB-2wknA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLY A 256
ILE A 260
TYR A 328
GLY A 360
None
0.75A 3n9jB-2wknA:
undetectable
3n9jB-2wknA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 11 ARG A 218
GLY A 156
SER A 247
GLY A 211
ASN A  22
None
1.28A 3v3nA-2wknA:
undetectable
3v3nA-2wknA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 11 ARG A 218
GLY A 156
SER A 247
GLY A 211
ASN A  22
None
1.29A 3v3nD-2wknA:
undetectable
3v3nD-2wknA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 GLY A 222
THR A 214
VAL A  89
PRO A 152
LEU A  91
None
1.18A 3v8vA-2wknA:
undetectable
3v8vA-2wknA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 ASN A  54
TRP A 102
ASP A  56
None
1.13A 4a7tA-2wknA:
undetectable
4a7tF-2wknA:
undetectable
4a7tA-2wknA:
19.12
4a7tF-2wknA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 11 ARG A 218
GLY A 156
SER A 247
GLY A 211
ASN A  22
None
1.23A 4a99D-2wknA:
undetectable
4a99D-2wknA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 9 THR A 214
LEU A 154
GLY A 249
THR A  44
VAL A  20
None
1.26A 4c9kA-2wknA:
undetectable
4c9kA-2wknA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 6 GLY A  74
PRO A  75
LEU A 246
VAL A  76
None
0.94A 4dubB-2wknA:
undetectable
4dubB-2wknA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 11 TYR A 302
GLY A 256
GLU A 259
HIS A 252
GLY A 264
None
None
ZN  A 411 ( 4.2A)
ZN  A 412 (-3.3A)
ZN  A 412 ( 4.6A)
1.37A 4ey7A-2wknA:
undetectable
4ey7A-2wknA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 11 TYR A 302
GLY A 256
GLU A 259
HIS A 252
GLY A 264
None
None
ZN  A 411 ( 4.2A)
ZN  A 412 (-3.3A)
ZN  A 412 ( 4.6A)
1.34A 4ey7B-2wknA:
undetectable
4ey7B-2wknA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 7 LEU A 306
ALA A 335
VAL A 358
THR A 379
None
0.98A 4eyrA-2wknA:
undetectable
4eyrA-2wknA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLN A 348
ILE A 397
TRP A 129
ASN A 145
None
0.99A 4fgjA-2wknA:
undetectable
4fgjB-2wknA:
undetectable
4fgjA-2wknA:
20.39
4fgjB-2wknA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLY A 270
GLY A 249
LEU A  72
VAL A  20
None
0.82A 4fgzA-2wknA:
undetectable
4fgzA-2wknA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 GLY A 106
GLY A 264
ILE A  52
ASP A  60
SER A 127
None
ZN  A 412 ( 4.6A)
None
None
None
1.02A 4iv0B-2wknA:
undetectable
4iv0B-2wknA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 HIS A  70
VAL A 272
LEU A 251
ZN  A 411 ( 4.8A)
None
None
0.62A 4m2vA-2wknA:
undetectable
4m2vA-2wknA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 5 LEU A  86
GLY A 282
ILE A 292
LYS A 294
None
1.17A 4ma8C-2wknA:
undetectable
4ma8C-2wknA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 SER A 363
ALA A 331
LEU A 375
GLY A 360
None
0.88A 4xk8a-2wknA:
undetectable
4xk8a-2wknA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 5 GLU A  43
THR A  44
HIS A 132
LEU A 101
None
1.29A 5axaA-2wknA:
undetectable
5axaA-2wknA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 ALA A  81
PRO A  83
GLY A 245
GLY A 243
LEU A 246
None
1.02A 5c0oH-2wknA:
undetectable
5c0oH-2wknA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 THR A 299
SER A 296
ASP A  93
None
0.85A 5kvaA-2wknA:
undetectable
5kvaA-2wknA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 THR A 299
SER A 296
ASP A  93
None
0.85A 5kvaB-2wknA:
undetectable
5kvaB-2wknA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 TRP A 167
PRO A  75
GLY A 156
GLY A 245
HIS A 220
None
1.07A 5nnaA-2wknA:
undetectable
5nnaA-2wknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 TRP A 167
PRO A  75
GLY A 156
GLY A 245
HIS A 220
None
1.06A 5nnaB-2wknA:
undetectable
5nnaB-2wknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 TRP A 167
PRO A  75
GLY A 156
GLY A 245
HIS A 220
None
1.05A 5nnaC-2wknA:
undetectable
5nnaC-2wknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)
2wkn FORMAMIDASE
(Delftia
acidovorans)
5 / 12 TRP A 167
PRO A  75
GLY A 156
GLY A 245
HIS A 220
None
1.06A 5nnaD-2wknA:
undetectable
5nnaD-2wknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLU A 267
VAL A  69
GLY A 153
LEU A 154
ZN  A 412 (-2.0A)
None
ZN  A 411 ( 4.3A)
None
0.96A 5sxtA-2wknA:
undetectable
5sxtA-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLU A 267
VAL A  69
GLY A 153
LEU A 154
ZN  A 412 (-2.0A)
None
ZN  A 411 ( 4.3A)
None
0.96A 5sxtB-2wknA:
undetectable
5sxtB-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 6 ARG A 218
HIS A 220
LEU A 158
PRO A  26
None
1.48A 5syjA-2wknA:
undetectable
5syjA-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 GLU A 267
VAL A  69
GLY A 153
LEU A 154
ZN  A 412 (-2.0A)
None
ZN  A 411 ( 4.3A)
None
0.96A 5syjB-2wknA:
undetectable
5syjB-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)
2wkn FORMAMIDASE
(Delftia
acidovorans)
4 / 8 ARG A 329
HIS A 120
LEU A 375
ILE A 336
None
0.98A 5v0vA-2wknA:
undetectable
5v0vA-2wknA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)
2wkn FORMAMIDASE
(Delftia
acidovorans)
3 / 3 ILE A 397
THR A 398
PRO A 142
None
0.51A 6ncsA-2wknA:
undetectable
6ncsA-2wknA:
21.71