SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 2wl1 PYRIN
(Homo
sapiens) 		4 / 6 HIS A 596
PHE A 721
ASP A 723
PRO A 588
 None
 1.46A 1ilqA-2wl1A:
undetectable
1ilqC-2wl1A:
undetectable		 1ilqA-2wl1A:
19.75
1ilqC-2wl1A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 1jffB-2wl1A:
undetectable		 1jffB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 10 VAL A 659
GLY A 660
THR A 735
ASN A 733
VAL A 718
 None
 1.25A 1pwyE-2wl1A:
undetectable		 1pwyE-2wl1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 10 VAL A 659
GLY A 660
THR A 735
ASN A 733
VAL A 718
 None
 1.32A 1v3qE-2wl1A:
undetectable		 1v3qE-2wl1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 LEU A 752
ILE A 755
ALA A 669
THR A 742
VAL A 690
 None
 1.04A 2fr3A-2wl1A:
undetectable		 2fr3A-2wl1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 LEU A 752
ILE A 755
ALA A 669
THR A 742
VAL A 690
 None
 1.07A 2g78A-2wl1A:
undetectable		 2g78A-2wl1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 2hxfB-2wl1A:
undetectable		 2hxfB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 2hxhB-2wl1A:
undetectable		 2hxhB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 2p4nB-2wl1A:
undetectable		 2p4nB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 2wbeB-2wl1A:
undetectable		 2wbeB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 3dcoB-2wl1A:
undetectable		 3dcoB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.10A 3edlB-2wl1A:
undetectable		 3edlB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 3iz0B-2wl1A:
undetectable		 3iz0B-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.14A 3j6pB-2wl1A:
undetectable		 3j6pB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 ILE A 601
GLY A 644
SER A 645
ARG A 676
ILE A 666
 None
 0.98A 3mb5A-2wl1A:
undetectable		 3mb5A-2wl1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 LEU A 611
LEU A 643
GLY A 644
ILE A 755
ALA A 669
 None
 1.09A 3uwlD-2wl1A:
undetectable		 3uwlD-2wl1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 11 THR A 606
ALA A 607
LEU A 611
VAL A 690
ILE A 674
 None
 1.39A 4claA-2wl1A:
undetectable		 4claA-2wl1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 10 VAL A 690
ALA A 669
PHE A 756
SER A 757
VAL A 691
 None
None
None
EDO  A1780 ( 4.6A)
None
 1.46A 4eilB-2wl1A:
undetectable		 4eilB-2wl1A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 10 VAL A 690
ALA A 669
PHE A 756
SER A 757
VAL A 691
 None
None
None
EDO  A1780 ( 4.6A)
None
 1.48A 4eilD-2wl1A:
undetectable		 4eilD-2wl1A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.05A 5hnwB-2wl1A:
undetectable		 5hnwB-2wl1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.10A 5hnyB-2wl1A:
undetectable		 5hnyB-2wl1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.09A 5hnzB-2wl1A:
undetectable		 5hnzB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 5ogcB-2wl1A:
undetectable		 5ogcB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2wl1 PYRIN
(Homo
sapiens) 		5 / 12 GLY A 668
VAL A 722
SER A 757
VAL A 690
LEU A 682
 None
None
EDO  A1780 ( 4.6A)
None
None
 1.15A 5ubbA-2wl1A:
undetectable		 5ubbA-2wl1A:
22.84