SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		3 / 3 GLU A 263
HIS A 212
ASP A 281
 FE  A1289 (-2.7A)
FE  A1289 (-3.6A)
None
 0.77A 1i9gA-2wl3A:
undetectable		 1i9gA-2wl3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 6 ALA A 226
TYR A  23
ILE A 215
PRO A 264
 None
 1.21A 1oniB-2wl3A:
undetectable
1oniC-2wl3A:
undetectable		 1oniB-2wl3A:
17.11
1oniC-2wl3A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 ALA A  63
LEU A 147
LEU A 213
SER A  13
LEU A  12
 None
 1.30A 2ceoB-2wl3A:
undetectable		 2ceoB-2wl3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 6 PRO A 135
MET A 136
ASP A 221
TYR A 225
 None
 1.44A 2lh8A-2wl3A:
undetectable		 2lh8A-2wl3A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 7 TYR A  23
LEU A 223
ALA A 226
PHE A 252
 None
 1.11A 2vcvA-2wl3A:
undetectable		 2vcvA-2wl3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 8 ILE A  65
TRP A  48
GLY A 148
ASN A 193
 None
 0.83A 4fgjA-2wl3A:
undetectable
4fgjB-2wl3A:
undetectable		 4fgjA-2wl3A:
21.88
4fgjB-2wl3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 8 GLY A  11
GLY A  66
GLU A 117
VAL A 102
 None
 0.88A 4fgzA-2wl3A:
undetectable		 4fgzA-2wl3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.68A 4ir0A-2wl3A:
7.4
4ir0B-2wl3A:
7.7		 4ir0A-2wl3A:
19.87
4ir0B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.60A 4ir0A-2wl3A:
7.4
4ir0B-2wl3A:
7.7		 4ir0A-2wl3A:
19.87
4ir0B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.62A 4jd1A-2wl3A:
7.4
4jd1B-2wl3A:
7.5		 4jd1A-2wl3A:
19.87
4jd1B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.72A 4jd1A-2wl3A:
7.4
4jd1B-2wl3A:
7.5		 4jd1A-2wl3A:
19.87
4jd1B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.59A 4jh3A-2wl3A:
3.5
4jh3B-2wl3A:
7.3		 4jh3A-2wl3A:
23.46
4jh3B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.57A 4jh3A-2wl3A:
3.5
4jh3B-2wl3A:
7.3		 4jh3A-2wl3A:
23.46
4jh3B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.57A 4jh4A-2wl3A:
7.3
4jh4B-2wl3A:
7.2		 4jh4A-2wl3A:
23.46
4jh4B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.58A 4jh4A-2wl3A:
7.3
4jh4B-2wl3A:
7.2		 4jh4A-2wl3A:
23.46
4jh4B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.57A 4jh5A-2wl3A:
7.2
4jh5B-2wl3A:
7.2		 4jh5A-2wl3A:
23.46
4jh5B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.58A 4jh5A-2wl3A:
7.2
4jh5B-2wl3A:
7.2		 4jh5A-2wl3A:
23.46
4jh5B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.59A 4jh6A-2wl3A:
7.3
4jh6B-2wl3A:
7.3		 4jh6A-2wl3A:
23.46
4jh6B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.60A 4jh6A-2wl3A:
7.3
4jh6B-2wl3A:
7.3		 4jh6A-2wl3A:
23.46
4jh6B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.58A 4jh8A-2wl3A:
7.2
4jh8B-2wl3A:
7.2		 4jh8A-2wl3A:
23.46
4jh8B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.57A 4jh8A-2wl3A:
7.2
4jh8B-2wl3A:
7.2		 4jh8A-2wl3A:
23.46
4jh8B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 7 LEU A  12
ALA A  24
MET A  30
MET A  45
 None
 0.98A 4rjdB-2wl3A:
undetectable		 4rjdB-2wl3A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 5 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.92A 4w5oA-2wl3A:
undetectable		 4w5oA-2wl3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 5 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.93A 4z4cA-2wl3A:
undetectable		 4z4cA-2wl3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 5 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.92A 4z4dA-2wl3A:
undetectable		 4z4dA-2wl3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 5 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.91A 4z4eA-2wl3A:
undetectable		 4z4eA-2wl3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 LEU A 105
PHE A 119
LEU A 147
LEU A   7
LEU A  62
 None
 0.93A 5iepA-2wl3A:
undetectable		 5iepA-2wl3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		4 / 6 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.90A 5t7bA-2wl3A:
undetectable		 5t7bA-2wl3A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		3 / 3 MET A 190
GLU A 158
ARG A 165
 None
 1.06A 5tjyA-2wl3A:
undetectable		 5tjyA-2wl3A:
23.05