SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.33A 1mj2B-2wl7A:
undetectable		 1mj2B-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.33A 1mj2D-2wl7A:
undetectable		 1mj2D-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.32A 1mjoB-2wl7A:
undetectable		 1mjoB-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.34A 1mjoA-2wl7A:
undetectable		 1mjoA-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.34A 1mjoD-2wl7A:
undetectable		 1mjoD-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 THR A 132
GLY A 117
ASP A 119
ALA A 168
 None
 1.21A 1sg9A-2wl7A:
undetectable		 1sg9A-2wl7A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		6 / 12 GLY A 138
ALA A 140
ASP A 143
ILE A 101
VAL A 148
ILE A 134
 None
None
None
None
SO4  A1191 (-3.9A)
None
 1.46A 3d1yA-2wl7A:
undetectable		 3d1yA-2wl7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		5 / 12 ALA A 175
LEU A 110
LEU A 181
VAL A 155
ILE A 114
 None
 1.12A 3fl9B-2wl7A:
undetectable		 3fl9B-2wl7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		6 / 12 GLY A 138
ALA A 140
ASP A 143
ILE A 101
VAL A 148
ILE A 134
 None
None
None
None
SO4  A1191 (-3.9A)
None
 1.42A 3k4vA-2wl7A:
undetectable		 3k4vA-2wl7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		6 / 12 GLY A 138
ALA A 140
ASP A 143
ILE A 101
VAL A 148
ILE A 134
 None
None
None
None
SO4  A1191 (-3.9A)
None
 1.41A 3ndtA-2wl7A:
undetectable		 3ndtA-2wl7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		6 / 12 GLY A 138
ALA A 140
ASP A 143
ILE A 101
VAL A 148
ILE A 134
 None
None
None
None
SO4  A1191 (-3.9A)
None
 1.46A 3tl9A-2wl7A:
undetectable		 3tl9A-2wl7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2wl7 DISKS LARGE HOMOLOG
2
(Mus
musculus) 		4 / 4 ASN A 149
SER A 161
LEU A 153
THR A 132
 CL  A1193 (-4.3A)
None
None
None
 1.25A 4an2A-2wl7A:
undetectable		 4an2A-2wl7A:
21.96