SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN
(Streptococcus
pyogenes) 		4 / 4 GLY A 143
ASP A 140
GLY A 135
THR A  14
 None
 0.96A 1hxbB-2wlaA:
undetectable		 1hxbB-2wlaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN
(Streptococcus
pyogenes) 		4 / 7 SER A 101
TYR A 127
VAL A 124
ASP A  38
 None
 0.98A 3bu1A-2wlaA:
undetectable		 3bu1A-2wlaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN
(Streptococcus
pyogenes) 		4 / 4 GLY A 143
ASP A 140
GLY A 135
THR A  14
 None
 0.96A 3k4vC-2wlaA:
undetectable		 3k4vC-2wlaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN
(Streptococcus
pyogenes) 		4 / 7 LEU A  83
ALA A  35
GLY A 135
ILE A 138
 None
 0.78A 3spkB-2wlaA:
undetectable		 3spkB-2wlaA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 LEU A  83
ASP A  38
LEU A 131
SER A  12
VAL A  13
 None
 1.05A 5km9B-2wlaA:
undetectable		 5km9B-2wlaA:
20.11