SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 LEU A  59
LEU A  80
ILE A  50
LEU A 146
VAL A 144
 None
 1.13A 2pnjA-2wlcA:
undetectable		 2pnjA-2wlcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 LEU A  74
LEU A  80
GLN A  83
LEU A  70
MET A  88
 None
None
EDO  A1218 (-3.7A)
None
None
 1.50A 2w8yB-2wlcA:
undetectable		 2w8yB-2wlcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 11 THR A  86
MET A  88
ILE A  67
ILE A  93
LEU A  59
 None
 1.32A 3a50C-2wlcA:
undetectable		 3a50C-2wlcA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 VAL A 156
VAL A 164
ILE A 140
VAL A 180
PHE A 174
 None
 1.32A 3cs9C-2wlcA:
undetectable		 3cs9C-2wlcA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 5 VAL A 189
ILE A 193
TYR A 200
MET A 199
 None
 0.96A 3gvuA-2wlcA:
undetectable		 3gvuA-2wlcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 LEU A  80
VAL A  65
ILE A  50
ILE A  67
TYR A 113
 None
 1.30A 3jw3B-2wlcA:
undetectable		 3jw3B-2wlcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 VAL A 144
PHE A 174
ILE A 158
ALA A 182
VAL A 150
 None
 1.18A 3me6C-2wlcA:
undetectable		 3me6C-2wlcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 VAL A 144
PHE A 174
ILE A 158
ALA A 182
VAL A 150
 None
 1.18A 3me6D-2wlcA:
undetectable		 3me6D-2wlcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		6 / 12 LEU A  28
LEU A  70
LEU A  80
LEU A  74
ILE A  17
ILE A  15
 None
 1.40A 4odrA-2wlcA:
undetectable
4odrB-2wlcA:
undetectable		 4odrA-2wlcA:
20.69
4odrB-2wlcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.82A 4zdzA-2wlcA:
undetectable		 4zdzA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.79A 4ze3A-2wlcA:
undetectable		 4ze3A-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.79A 5eseA-2wlcA:
undetectable		 5eseA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.77A 5esfA-2wlcA:
undetectable		 5esfA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.80A 5esjA-2wlcA:
undetectable		 5esjA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.80A 5esmA-2wlcA:
undetectable		 5esmA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 ILE A 115
GLU A  92
GLY A  91
CYH A 107
THR A  86
 None
 1.40A 5fhzD-2wlcA:
undetectable		 5fhzD-2wlcA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.79A 5hs1A-2wlcA:
undetectable		 5hs1A-2wlcA:
17.59