SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		4 / 6 GLN A 295
GLY A 269
HIS A 297
HIS A 298
 None
 1.11A 3ai8B-2wliA:
undetectable		 3ai8B-2wliA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		5 / 10 ALA A 259
ILE A 224
PRO A 223
LEU A 232
ILE A 265
 None
 1.09A 3hbbA-2wliA:
undetectable		 3hbbA-2wliA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		5 / 9 PHE A 239
LEU A 232
THR A 231
LEU A 159
ILE A 224
 None
 0.96A 3tbgD-2wliA:
undetectable		 3tbgD-2wliA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		5 / 12 SER A 205
SER A 209
LEU A 285
VAL A 274
PHE A 290
 None
 1.10A 3u9fJ-2wliA:
undetectable
3u9fK-2wliA:
undetectable		 3u9fJ-2wliA:
20.00
3u9fK-2wliA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		5 / 12 SER A 205
SER A 209
LEU A 285
VAL A 274
PHE A 290
 None
 1.10A 3u9fJ-2wliA:
undetectable
3u9fL-2wliA:
undetectable		 3u9fJ-2wliA:
20.00
3u9fL-2wliA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		5 / 11 HIS A 291
SER A 146
GLU A 264
TRP A 267
LEU A 232
 None
 1.49A 4foxC-2wliA:
undetectable		 4foxC-2wliA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		4 / 4 HIS A 236
GLU A 184
HIS A 196
LEU A 159
 None
 1.39A 4m2rA-2wliA:
undetectable		 4m2rA-2wliA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2wli POTASSIUM CHANNEL
(Magnetospirillum
magnetotacticum) 		3 / 3 HIS A 221
ASP A 219
HIS A 220
 None
 0.90A 5n1tW-2wliA:
5.3		 5n1tW-2wliA:
21.26