SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 11 LEU A  73
ASP A  64
GLY A  15
ILE A  17
VAL A  57
 None
None
ASP  A1333 (-3.2A)
None
None
 0.98A 1hxwB-2wltA:
undetectable		 1hxwB-2wltA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		3 / 3 GLU A  99
LYS A 178
VAL A 167
 None
 0.96A 1l2iA-2wltA:
undetectable		 1l2iA-2wltA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 10 GLY A  35
VAL A  36
LEU A  40
LEU A 135
ALA A  12
 None
 1.23A 1pbcA-2wltA:
undetectable		 1pbcA-2wltA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		4 / 8 HIS A  93
GLY A  14
THR A  97
ILE A  60
 None
 0.84A 2a8tB-2wltA:
undetectable		 2a8tB-2wltA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 LEU A  73
ASP A  64
GLY A  15
ILE A  17
VAL A  57
 None
None
ASP  A1333 (-3.2A)
None
None
 0.89A 2nnkB-2wltA:
undetectable		 2nnkB-2wltA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 11 LEU A  73
ASP A  64
GLY A  15
ILE A  17
VAL A  57
 None
None
ASP  A1333 (-3.2A)
None
None
 0.86A 2o4pA-2wltA:
undetectable		 2o4pA-2wltA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		4 / 8 LEU A  46
VAL A 139
GLN A  53
ARG A  51
 None
 0.68A 2wd9B-2wltA:
2.9		 2wd9B-2wltA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 10 PHE A 235
SER A 238
SER A 241
GLY A 271
ALA A 267
 None
 1.14A 2x2iB-2wltA:
undetectable		 2x2iB-2wltA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 PHE A 235
SER A 238
SER A 241
GLY A 271
ALA A 267
 None
 1.26A 2x2iC-2wltA:
undetectable		 2x2iC-2wltA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		3 / 3 HIS A 110
GLU A 206
HIS A 203
 None
 0.88A 3ba0A-2wltA:
undetectable		 3ba0A-2wltA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 LEU A  73
ASP A  64
GLY A  15
ILE A  17
VAL A  57
 None
None
ASP  A1333 (-3.2A)
None
None
 0.84A 3k4vA-2wltA:
undetectable		 3k4vA-2wltA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 11 ILE A 248
ILE A 274
LEU A 239
ALA A 263
ILE A 290
 None
 0.97A 4h1nA-2wltA:
undetectable		 4h1nA-2wltA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 LEU A 261
GLY A 259
MET A 230
ILE A 274
PHE A 235
 None
 1.30A 4p6xE-2wltA:
undetectable		 4p6xE-2wltA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 LEU A  39
GLY A 131
GLY A 119
VAL A 118
THR A  92
 None
 0.97A 5o4yD-2wltA:
undetectable
5o4yE-2wltA:
undetectable		 5o4yD-2wltA:
2.84
5o4yE-2wltA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 GLY A 151
HIS A 203
SER A 140
VAL A 188
ILE A 160
 None
 1.03A 6bxnB-2wltA:
undetectable		 6bxnB-2wltA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 ALA A  24
ASN A 123
GLY A  21
SER A  20
GLY A  19
 None
 0.93A 6c79A-2wltA:
undetectable		 6c79A-2wltA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 2wlt L-ASPARAGINASE
(Helicobacter
pylori) 		5 / 12 LEU A  73
ASP A  64
GLY A  15
ILE A  17
VAL A  57
 None
None
ASP  A1333 (-3.2A)
None
None
 0.85A 6dilA-2wltA:
undetectable		 6dilA-2wltA:
15.66