SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.45A 1dz9A-2wm4A:
42.1		 1dz9A-2wm4A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		3 / 4 VAL A 305
TRP A 311
TRP A 293
 None
 1.37A 1gmkC-2wm4A:
undetectable
1gmkD-2wm4A:
undetectable		 1gmkC-2wm4A:
3.35
1gmkD-2wm4A:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
PHE A 260
LEU A 238
ILE A 111
VAL A 133
 HEM  A 450 (-4.5A)
None
None
HEM  A 450 (-4.3A)
None
 1.44A 1hrkB-2wm4A:
undetectable		 1hrkB-2wm4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.55A 1uyuA-2wm4A:
42.0		 1uyuA-2wm4A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 262
ILE A 197
PHE A 212
ILE A 111
PHE A 416
 None
None
None
HEM  A 450 (-4.3A)
None
 1.24A 2ygpA-2wm4A:
0.0		 2ygpA-2wm4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.70A 2zaxA-2wm4A:
41.6		 2zaxA-2wm4A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 267
THR A 271
CYH A 379
 HEM  A 450 (-3.3A)
HEM  A 450 (-3.1A)
HEM  A 450 (-2.3A)
 0.50A 3e4eA-2wm4A:
30.1		 3e4eA-2wm4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 267
THR A 271
CYH A 379
 HEM  A 450 (-3.3A)
HEM  A 450 (-3.1A)
HEM  A 450 (-2.3A)
 0.41A 3e4eB-2wm4A:
29.9		 3e4eB-2wm4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.66A 3fwgB-2wm4A:
41.5		 3fwgB-2wm4A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.72A 3fwiA-2wm4A:
41.4		 3fwiA-2wm4A:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
THR A 271
LEU A 263
MET A 318
PHE A 416
 None
HEM  A 450 (-3.1A)
HEM  A 450 ( 4.5A)
HEM  A 450 ( 4.4A)
None
 1.29A 3g1uB-2wm4A:
undetectable		 3g1uB-2wm4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
THR A 271
LEU A 263
MET A 318
PHE A 416
 None
HEM  A 450 (-3.1A)
HEM  A 450 ( 4.5A)
HEM  A 450 ( 4.4A)
None
 1.30A 3g1uD-2wm4A:
undetectable		 3g1uD-2wm4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 276
PHE A 393
ASP A 394
GLU A 395
 None
 0.87A 3kp6A-2wm4A:
1.0
3kp6B-2wm4A:
undetectable		 3kp6A-2wm4A:
15.78
3kp6B-2wm4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
THR A 271
LEU A 263
MET A 318
PHE A 416
 None
HEM  A 450 (-3.1A)
HEM  A 450 ( 4.5A)
HEM  A 450 ( 4.4A)
None
 1.29A 3n58D-2wm4A:
undetectable		 3n58D-2wm4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
PHE A 260
LEU A 238
ILE A 111
VAL A 133
 HEM  A 450 (-4.5A)
None
None
HEM  A 450 (-4.3A)
None
 1.42A 3w1wB-2wm4A:
undetectable		 3w1wB-2wm4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 191
LEU A 171
LEU A 423
ILE A 420
LEU A 283
 None
 1.00A 4dm8B-2wm4A:
undetectable		 4dm8B-2wm4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 169
PRO A 170
LEU A 163
VAL A 164
 None
 0.85A 4dubB-2wm4A:
30.4		 4dubB-2wm4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 9 PHE A 129
PHE A 260
ILE A 111
MET A 110
 None
None
HEM  A 450 (-4.3A)
HEM  A 450 ( 4.4A)
 1.16A 4jvlA-2wm4A:
undetectable		 4jvlA-2wm4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 175
ASP A 394
GLU A 388
VAL A 134
 None
None
HEM  A 450 ( 4.2A)
None
 1.24A 4nkxD-2wm4A:
29.7		 4nkxD-2wm4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 169
ALA A 168
ILE A 420
PRO A 314
THR A 277
 None
None
None
HEM  A 450 ( 4.2A)
None
 0.99A 4xdrA-2wm4A:
undetectable		 4xdrA-2wm4A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 270
ILE A 190
ARG A 144
ILE A 176
 None
None
None
HEM  A 450 (-4.9A)
 0.95A 4xumA-2wm4A:
undetectable		 4xumA-2wm4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 349
VAL A  78
LEU A 369
 None
 0.65A 5e5jB-2wm4A:
undetectable		 5e5jB-2wm4A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
THR A 271
LEU A 263
MET A 318
PHE A 416
 None
HEM  A 450 (-3.1A)
HEM  A 450 ( 4.5A)
HEM  A 450 ( 4.4A)
None
 1.29A 5m66A-2wm4A:
undetectable		 5m66A-2wm4A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 199
ARG A 273
ASN A 195
LEU A 198
 None
 1.13A 6b58A-2wm4A:
undetectable		 6b58A-2wm4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2wm4 PUTATIVE CYTOCHROME
P450 124
(Mycobacterium
tuberculosis) 		4 / 5 ALA A  81
TYR A  80
GLN A 324
ILE A 326
 None
 1.20A 6g9bA-2wm4A:
undetectable
6g9bB-2wm4A:
undetectable		 6g9bA-2wm4A:
10.59
6g9bB-2wm4A:
12.11