SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.71A 1rtsA-2wmcA:
undetectable		 1rtsA-2wmcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.76A 1rtsB-2wmcA:
undetectable		 1rtsB-2wmcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.69A 2tsrA-2wmcA:
undetectable		 2tsrA-2wmcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.78A 2tsrB-2wmcA:
undetectable		 2tsrB-2wmcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		5 / 11 ASP A 142
VAL A 170
ALA A 108
PHE A 110
PHE A  61
 None
 1.35A 3n23A-2wmcA:
undetectable		 3n23A-2wmcA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		5 / 11 ASP A 142
VAL A 170
ALA A 108
PHE A 110
PHE A  61
 None
 1.35A 3n23C-2wmcA:
undetectable		 3n23C-2wmcA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 4 ASN A 128
ALA A 184
GLY A 129
THR A 181
 None
 1.36A 4bboC-2wmcA:
undetectable		 4bboC-2wmcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.67A 4iqqA-2wmcA:
undetectable		 4iqqA-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.63A 4iqqB-2wmcA:
undetectable		 4iqqB-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.67A 4iqqC-2wmcA:
undetectable		 4iqqC-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.65A 4iqqD-2wmcA:
undetectable		 4iqqD-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.66A 5h3aA-2wmcA:
undetectable		 5h3aA-2wmcA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.72A 5h3aB-2wmcA:
undetectable		 5h3aB-2wmcA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.65A 5nooA-2wmcA:
undetectable		 5nooA-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.64A 5nooB-2wmcA:
undetectable		 5nooB-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.63A 5nooD-2wmcA:
undetectable		 5nooD-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		3 / 3 LYS A 131
TRP A 132
SER A 178
 None
 1.28A 5nwwA-2wmcA:
undetectable		 5nwwA-2wmcA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 7 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.72A 5x5qC-2wmcA:
undetectable		 5x5qC-2wmcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.75A 5x5qD-2wmcA:
undetectable		 5x5qD-2wmcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Pisum
sativum) 		4 / 8 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.76A 5x5qF-2wmcA:
undetectable		 5x5qF-2wmcA:
19.93