SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 TRP A  62
GLY A  54
ASN A  57
PRO A  88
 None
 0.78A 1dedA-2wmhA:
9.3		 1dedA-2wmhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 466
LEU A 456
HIS A 581
LEU A 489
ILE A 487
 None
 1.33A 1fmlA-2wmhA:
undetectable		 1fmlA-2wmhA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A  85
HIS A  87
ASP A 251
 None
FUC  A1591 (-4.0A)
None
 0.82A 1i9gA-2wmhA:
undetectable		 1i9gA-2wmhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 360
GLU A 410
SER A 408
THR A 405
 None
 1.15A 1icuA-2wmhA:
undetectable
1icuB-2wmhA:
undetectable		 1icuA-2wmhA:
16.64
1icuB-2wmhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 SER A 408
THR A 405
PHE A 360
GLU A 410
 None
 1.17A 1icuC-2wmhA:
undetectable
1icuD-2wmhA:
undetectable		 1icuC-2wmhA:
16.64
1icuD-2wmhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 SER A 408
THR A 405
PHE A 360
GLU A 410
 None
 1.10A 1kqbA-2wmhA:
undetectable
1kqbB-2wmhA:
undetectable		 1kqbA-2wmhA:
17.10
1kqbB-2wmhA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 SER A 408
THR A 405
PHE A 360
GLU A 410
 None
 1.13A 1kqbC-2wmhA:
undetectable
1kqbD-2wmhA:
undetectable		 1kqbC-2wmhA:
17.10
1kqbD-2wmhA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 533
ASN A 582
THR A 563
 None
 0.76A 2pymB-2wmhA:
undetectable		 2pymB-2wmhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 533
ASN A 582
THR A 563
 None
 0.80A 2q63B-2wmhA:
undetectable		 2q63B-2wmhA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 SER A 171
LEU A 167
ILE A 198
PHE A 204
LEU A 155
 None
 1.35A 3a9eB-2wmhA:
undetectable		 3a9eB-2wmhA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 TYR A 374
PHE A 360
GLU A 369
SER A 235
TYR A 365
 None
 1.49A 3apwA-2wmhA:
undetectable		 3apwA-2wmhA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ALA A  70
ALA A  73
ILE A  84
GLU A  85
 None
 0.84A 3dtuC-2wmhA:
undetectable
3dtuD-2wmhA:
undetectable		 3dtuC-2wmhA:
19.63
3dtuD-2wmhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 MET A 128
CYH A 178
PRO A 138
 None
 0.88A 3h52C-2wmhA:
undetectable		 3h52C-2wmhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 LEU A 364
TYR A 422
GLY A 377
LEU A 382
TYR A 361
 None
 1.15A 3hvtA-2wmhA:
0.7		 3hvtA-2wmhA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 468
LEU A 466
LEU A 543
ILE A 577
ILE A 487
 None
 1.12A 4a7aB-2wmhA:
undetectable		 4a7aB-2wmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ASP A 226
ARG A 225
GLY A 359
GLN A 362
 None
 0.89A 4af0A-2wmhA:
10.8		 4af0A-2wmhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PRO A 334
TYR A 291
GLY A 295
 None
 0.73A 4g2zA-2wmhA:
undetectable		 4g2zA-2wmhA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 466
THR A 539
LEU A 543
VAL A 579
 None
 0.80A 4iizB-2wmhA:
2.2		 4iizB-2wmhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 466
THR A 539
LEU A 543
VAL A 579
 None
 0.77A 4ik6B-2wmhA:
undetectable		 4ik6B-2wmhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 440
THR A 252
THR A 306
THR A 474
 None
 1.02A 4mbsA-2wmhA:
undetectable		 4mbsA-2wmhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 459
THR A 539
LEU A 489
THR A 474
 None
 0.80A 4mbsA-2wmhA:
undetectable		 4mbsA-2wmhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A 230
THR A 219
ASP A 231
TYR A 374
 None
 1.35A 4oltA-2wmhA:
undetectable		 4oltA-2wmhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A 230
THR A 219
ASP A 231
TYR A 374
 None
 1.37A 4oltB-2wmhA:
undetectable		 4oltB-2wmhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 THR A 135
HIS A 170
LEU A 167
ASN A 159
 None
 0.93A 4pfjA-2wmhA:
undetectable		 4pfjA-2wmhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLN A 209
LEU A 242
SER A 208
ASP A 201
 None
 1.36A 4qtuD-2wmhA:
undetectable		 4qtuD-2wmhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A 230
THR A 219
ASP A 231
TYR A 374
 None
 1.37A 4qwpA-2wmhA:
undetectable		 4qwpA-2wmhA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A 230
THR A 219
ASP A 231
TYR A 374
 None
 1.33A 4qwpB-2wmhA:
undetectable		 4qwpB-2wmhA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 229
TYR A 160
ASP A 227
ALA A 228
TYR A 365
 None
 1.38A 4ymgB-2wmhA:
undetectable		 4ymgB-2wmhA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 493
ASN A 491
ASP A 469
 None
 0.89A 5gwxA-2wmhA:
undetectable		 5gwxA-2wmhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 VAL A 574
LEU A 468
SER A 467
ILE A 441
 None
 0.94A 5jw1A-2wmhA:
undetectable		 5jw1A-2wmhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A 516
THR A 252
TYR A 275
TYR A  53
 None
None
None
FUC  A1591 (-4.6A)
 1.44A 5lrbA-2wmhA:
undetectable		 5lrbA-2wmhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 PHE A 360
LEU A 364
SER A 232
GLY A 229
ILE A 354
 None
 1.17A 6ebpB-2wmhA:
undetectable		 6ebpB-2wmhA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 PHE A 360
LEU A 364
SER A 232
GLY A 229
ILE A 354
 None
 1.14A 6ebpC-2wmhA:
undetectable		 6ebpC-2wmhA:
12.39