SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RMT_B_ADNB1502_1 (CLASS B ACID PHOSPHATASE)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 7	PHE A 149 LEU A 10 THR A 151 TYR A 150	None	1.09A	1rmtB-2wn2A: undetectable	1rmtB-2wn2A: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGN_A_ACTA1181_0 (WNT INHIBITORY FACTOR 1)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	3 / 3	TYR A 89 VAL A 74 THR A 110	None None GOL A 500 (-4.0A)	0.87A	2ygnA-2wn2A: undetectable	2ygnA-2wn2A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJE_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	5 / 12	PHE A 71 ALA A 129 LEU A 17 ILE A 91 LEU A 10	None	1.08A	5ljeA-2wn2A: undetectable	5ljeA-2wn2A: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X19_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 5	ARG A 128 MET A 72 THR A 151 LEU A 6	None	1.03A	5x19J-2wn2A: undetectable	5x19J-2wn2A: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1B_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 5	ARG A 128 MET A 72 THR A 151 LEU A 6	None	1.06A	5x1bJ-2wn2A: undetectable	5x1bJ-2wn2A: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1B_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 5	ARG A 128 MET A 72 THR A 151 LEU A 6	None	1.14A	5x1bW-2wn2A: undetectable	5x1bW-2wn2A: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 6	ARG A 128 MET A 72 THR A 151 LEU A 6	None	1.08A	5x1fA-2wn2A: undetectable 5x1fJ-2wn2A: undetectable	5x1fA-2wn2A: 18.15 5x1fJ-2wn2A: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ102_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2wn2	DISCOIDIN-1 SUBUNIT A (Dictyostelium discoideum)	4 / 5	ARG A 128 MET A 72 THR A 151 LEU A 6	None	1.06A	6nknJ-2wn2A: undetectable	6nknJ-2wn2A: 15.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RMT_B_ADNB1502_1","CLASS B ACID PHOSPHATASE","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"PHE A 149;LEU A  10;THR A 151;TYR A 150","None","1.09A","1rmtB-2wn2A:undetectable","1rmtB-2wn2A:22.76"],["2YGN_A_ACTA1181_0","WNT INHIBITORY FACTOR 1","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",3,"TYR A  89;VAL A  74;THR A 110","None;None;GOL A 500 (-4.0A)","0.87A","2ygnA-2wn2A:undetectable","2ygnA-2wn2A:20.00"],["5LJE_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",5,"PHE A  71;ALA A 129;LEU A  17;ILE A  91;LEU A  10","None","1.08A","5ljeA-2wn2A:undetectable","5ljeA-2wn2A:18.40"],["5X19_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"ARG A 128;MET A  72;THR A 151;LEU A   6","None","1.03A","5x19J-2wn2A:undetectable","5x19J-2wn2A:15.15"],["5X1B_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"ARG A 128;MET A  72;THR A 151;LEU A   6","None","1.06A","5x1bJ-2wn2A:undetectable","5x1bJ-2wn2A:15.15"],["5X1B_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"ARG A 128;MET A  72;THR A 151;LEU A   6","None","1.14A","5x1bW-2wn2A:undetectable","5x1bW-2wn2A:15.15"],["5X1F_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"ARG A 128;MET A  72;THR A 151;LEU A   6","None","1.08A","5x1fA-2wn2A:undetectable;5x1fJ-2wn2A:undetectable","5x1fA-2wn2A:18.15;5x1fJ-2wn2A:15.15"],["6NKN_J_CHDJ102_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2wn2","DISCOIDIN-1 SUBUNIT A","Dictyostelium discoideum",4,"ARG A 128;MET A  72;THR A 151;LEU A   6","None","1.06A","6nknJ-2wn2A:undetectable","6nknJ-2wn2A:15.15"]]