SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 10 GLU A  79
GLU A  82
GLU A  42
LEU A  38
GLU A  47
 None
 1.46A 1a29A-2wn4A:
undetectable		 1a29A-2wn4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 ARG A 364
GLY A 189
ASP A 141
 None
 0.59A 1kf6A-2wn4A:
undetectable
1kf6B-2wn4A:
undetectable		 1kf6A-2wn4A:
19.90
1kf6B-2wn4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 ASP A 195
LEU A 165
LEU A 167
PRO A 168
TYR A 190
 None
 1.47A 1p33C-2wn4A:
undetectable		 1p33C-2wn4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 8 PHE A 396
LEU A 418
ILE A 367
THR A 346
 None
 0.93A 1sbrA-2wn4A:
undetectable		 1sbrA-2wn4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 6 LYS A 397
ALA A 416
LEU A 418
VAL A 414
 None
 1.06A 1sn5A-2wn4A:
undetectable		 1sn5A-2wn4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 8 LYS A 397
ALA A 416
LEU A 418
VAL A 414
 None
 1.01A 1sn5C-2wn4A:
undetectable		 1sn5C-2wn4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 7 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.04A 2c8aA-2wn4A:
22.8		 2c8aA-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 7 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.19A 2c8aB-2wn4A:
23.3		 2c8aB-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 6 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.06A 2c8aC-2wn4A:
22.9		 2c8aC-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 7 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.12A 2c8aD-2wn4A:
23.4		 2c8aD-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 8 ASN A 263
ILE A 266
TYR A 253
ARG A 302
 None
 1.05A 2v57A-2wn4A:
undetectable		 2v57A-2wn4A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 8 ASN A 263
ILE A 266
TYR A 253
ARG A 302
 None
 1.05A 2v57C-2wn4A:
undetectable		 2v57C-2wn4A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 4 ILE A 194
PHE A 107
ILE A 192
THR A 132
 None
 1.16A 3ia4A-2wn4A:
undetectable		 3ia4A-2wn4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.15A 3ko0A-2wn4A:
undetectable
3ko0B-2wn4A:
undetectable
3ko0C-2wn4A:
undetectable
3ko0D-2wn4A:
undetectable		 3ko0A-2wn4A:
13.10
3ko0B-2wn4A:
13.10
3ko0C-2wn4A:
13.10
3ko0D-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 11 ASP A 141
LEU A 363
ILE A 398
PHE A 107
ASP A 402
 None
 1.13A 3ko0A-2wn4A:
undetectable
3ko0B-2wn4A:
undetectable
3ko0C-2wn4A:
undetectable
3ko0D-2wn4A:
undetectable		 3ko0A-2wn4A:
13.10
3ko0B-2wn4A:
13.10
3ko0C-2wn4A:
13.10
3ko0D-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 11 ASP A 402
LEU A 363
ILE A 398
PHE A 107
ASP A 141
 None
 1.18A 3ko0C-2wn4A:
undetectable
3ko0D-2wn4A:
undetectable
3ko0E-2wn4A:
undetectable
3ko0F-2wn4A:
undetectable		 3ko0C-2wn4A:
13.10
3ko0D-2wn4A:
13.10
3ko0E-2wn4A:
13.10
3ko0F-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 ASP A 402
LEU A 363
ILE A 398
PHE A 107
ASP A 141
 None
 1.17A 3ko0G-2wn4A:
undetectable
3ko0H-2wn4A:
undetectable
3ko0I-2wn4A:
undetectable
3ko0J-2wn4A:
undetectable		 3ko0G-2wn4A:
13.10
3ko0H-2wn4A:
13.10
3ko0I-2wn4A:
13.10
3ko0J-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 11 ASP A 141
ASP A 402
LEU A 363
ILE A 398
PHE A 107
 None
 1.15A 3ko0A-2wn4A:
undetectable
3ko0B-2wn4A:
undetectable
3ko0I-2wn4A:
undetectable
3ko0J-2wn4A:
undetectable		 3ko0A-2wn4A:
13.10
3ko0B-2wn4A:
13.10
3ko0I-2wn4A:
13.10
3ko0J-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.16A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0S-2wn4A:
undetectable
3ko0T-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0S-2wn4A:
13.10
3ko0T-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 ASP A 402
LEU A 363
ILE A 398
PHE A 107
ASP A 141
 None
 1.19A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 12 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.15A 3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable
3ko0O-2wn4A:
undetectable
3ko0P-2wn4A:
undetectable		 3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
3ko0O-2wn4A:
13.10
3ko0P-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 11 ASP A 141
ASP A 402
LEU A 363
ILE A 398
PHE A 107
 None
 1.22A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 11 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.16A 3ko0O-2wn4A:
undetectable
3ko0P-2wn4A:
undetectable
3ko0Q-2wn4A:
undetectable
3ko0R-2wn4A:
undetectable		 3ko0O-2wn4A:
13.10
3ko0P-2wn4A:
13.10
3ko0Q-2wn4A:
13.10
3ko0R-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		5 / 10 ASP A 141
LEU A 363
ILE A 398
PHE A 107
ASP A 402
 None
 1.18A 3ko0O-2wn4A:
undetectable
3ko0P-2wn4A:
undetectable
3ko0Q-2wn4A:
undetectable
3ko0R-2wn4A:
undetectable		 3ko0O-2wn4A:
13.10
3ko0P-2wn4A:
13.10
3ko0Q-2wn4A:
13.10
3ko0R-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 SER A 377
GLY A 384
SER A 347
 None
 0.69A 3loqA-2wn4A:
undetectable		 3loqA-2wn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 ASP A 219
GLU A 187
SER A 347
 None
 0.76A 3p2kA-2wn4A:
undetectable		 3p2kA-2wn4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 7 ASP A 145
ILE A  34
SER A 183
TYR A 176
 None
 0.90A 3pglA-2wn4A:
undetectable		 3pglA-2wn4A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 5 PHE A 396
GLY A 373
ILE A 365
VAL A 300
 None
 0.88A 3wrkA-2wn4A:
undetectable		 3wrkA-2wn4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 ASN A 234
TRP A 230
ASP A 237
 None
 1.13A 4a7tA-2wn4A:
undetectable
4a7tF-2wn4A:
undetectable		 4a7tA-2wn4A:
14.29
4a7tF-2wn4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 4 THR A 366
GLY A 189
ASP A 141
SER A 217
 None
 1.38A 4rfqA-2wn4A:
undetectable		 4rfqA-2wn4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 6 LEU A 185
GLU A 187
ILE A  34
PRO A 168
 None
 1.03A 4xi3C-2wn4A:
undetectable		 4xi3C-2wn4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		4 / 7 TYR A 258
ARG A 302
SER A 345
GLU A 387
 None
 0.62A 4xzkA-2wn4A:
15.0		 4xzkA-2wn4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 PHE A 309
ILE A 361
ASP A 319
 None
 0.77A 5cswA-2wn4A:
undetectable		 5cswA-2wn4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 PHE A 309
ILE A 361
ASP A 319
 None
 0.73A 5cswB-2wn4A:
undetectable		 5cswB-2wn4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT
(Clostridioides
difficile) 		3 / 3 ASP A 219
SER A 350
TYR A 301
 None
 0.66A 5glmA-2wn4A:
undetectable		 5glmA-2wn4A:
21.04