SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 LEU A 111
HIS A  24
SER A  77
ILE A  76
ILE A  81
 None
 1.42A 1ot7B-2wngA:
undetectable		 1ot7B-2wngA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 ILE A 149
ASP A 148
THR A 150
VAL A 199
PRO A 117
 None
 1.25A 2yzqA-2wngA:
undetectable		 2yzqA-2wngA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1
(Homo
sapiens) 		4 / 6 ALA A 129
VAL A 221
ASP A 190
GLU A 189
 None
 0.89A 4g24A-2wngA:
undetectable		 4g24A-2wngA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 SER A  29
LEU A   4
PRO A  32
VAL A  33
PHE A 103
 None
 1.20A 5jo9A-2wngA:
undetectable		 5jo9A-2wngA:
20.43