SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 7 ALA F 189
TYR F 191
SER F 278
ALA F 280
 None
 1.07A 1k5qA-2wnpF:
undetectable
1k5qB-2wnpF:
undetectable		 1k5qA-2wnpF:
22.31
1k5qB-2wnpF:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 6 ARG F 132
GLY F 247
TYR F 251
TRP F 249
 None
 1.31A 1kf6M-2wnpF:
undetectable
1kf6N-2wnpF:
undetectable		 1kf6M-2wnpF:
16.58
1kf6N-2wnpF:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 6 LEU F 179
VAL F 180
TRP F 277
TYR F 191
 None
 0.89A 1s9qA-2wnpF:
undetectable		 1s9qA-2wnpF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 11 GLY F 274
LEU F 262
SER F 290
ARG F 132
ASN F 258
 None
 1.29A 2h21B-2wnpF:
undetectable		 2h21B-2wnpF:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 11 PRO F  86
ARG F  87
VAL F 115
GLY F 155
GLU F 156
 None
 1.43A 2h9tH-2wnpF:
undetectable		 2h9tH-2wnpF:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		8 / 10 SER F 100
LEU F 116
ASP F 118
ASP F 120
THR F 121
ARG F 131
GLU F 291
LYS F 293
 None
 0.55A 2j1gE-2wnpF:
40.7
2j1gF-2wnpF:
40.6		 2j1gE-2wnpF:
83.49
2j1gF-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 5 ASP F 134
SER F 136
LEU F 154
GLY F 155
 None
 0.30A 2j2pA-2wnpF:
39.4
2j2pB-2wnpF:
40.5		 2j2pA-2wnpF:
83.49
2j2pB-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 8 SER F 100
ASP F 118
ASP F 120
ARG F 131
GLU F 291
 None
 0.53A 2j2pA-2wnpF:
39.4
2j2pB-2wnpF:
40.5		 2j2pA-2wnpF:
83.49
2j2pB-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 8 SER F 100
LEU F 116
ASP F 118
ASP F 120
ARG F 131
 None
 0.24A 2j2pA-2wnpF:
39.4
2j2pB-2wnpF:
40.5		 2j2pA-2wnpF:
83.49
2j2pB-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 9 SER F 100
LEU F 116
ASP F 118
ASP F 120
GLU F 291
 None
 0.48A 2j2pB-2wnpF:
40.5
2j2pC-2wnpF:
39.7		 2j2pB-2wnpF:
83.49
2j2pC-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 6 ASP F 134
SER F 136
SER F 152
LEU F 154
GLY F 155
 None
 0.23A 2j2pA-2wnpF:
39.4
2j2pC-2wnpF:
39.7		 2j2pA-2wnpF:
83.49
2j2pC-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 6 ASP F 138
ARG F 141
ASP F 142
LYS F 230
 None
 0.56A 2j2pE-2wnpF:
40.5
2j2pF-2wnpF:
39.6		 2j2pE-2wnpF:
83.49
2j2pF-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 9 SER F 100
LEU F 116
ASP F 118
ARG F 131
GLU F 291
 None
 0.49A 2j2pD-2wnpF:
39.6
2j2pE-2wnpF:
40.5		 2j2pD-2wnpF:
83.49
2j2pE-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 6 ASP F 134
SER F 136
SER F 152
LEU F 154
GLY F 155
 None
 0.28A 2j2pD-2wnpF:
39.6
2j2pF-2wnpF:
39.6		 2j2pD-2wnpF:
83.49
2j2pF-2wnpF:
83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 6 SER F 100
ASP F 118
ASP F 120
GLU F 291
 None
 0.45A 2j2pE-2wnpF:
40.5
2j2pF-2wnpF:
39.6		 2j2pE-2wnpF:
83.49
2j2pF-2wnpF:
83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 8 PHE F 150
TYR F 140
PHE F 227
ASN F 161
 None
 1.25A 2wekA-2wnpF:
undetectable		 2wekA-2wnpF:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 8 PHE F 150
TYR F 140
PHE F 227
ASN F 161
 None
 1.24A 2wekB-2wnpF:
undetectable		 2wekB-2wnpF:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 10 SER F 218
SER F 278
TRP F 277
GLY F 213
ALA F 189
 None
 1.29A 2x2iB-2wnpF:
undetectable		 2x2iB-2wnpF:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 SER F 100
GLU F 291
ASP F 120
 None
 0.76A 2zthA-2wnpF:
undetectable		 2zthA-2wnpF:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 11 PRO F  86
ARG F  87
VAL F 115
GLY F 155
GLU F 156
 None
 1.43A 3bf6H-2wnpF:
undetectable		 3bf6H-2wnpF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 SER F 100
GLU F 291
ASP F 120
 None
 0.80A 3bwmA-2wnpF:
undetectable		 3bwmA-2wnpF:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 SER F 100
GLU F 291
ASP F 120
 None
 0.78A 3bwyA-2wnpF:
undetectable		 3bwyA-2wnpF:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 7 GLY F 160
MET F 133
PHE F 139
GLY F 151
 None
 0.98A 3ko0M-2wnpF:
undetectable
3ko0P-2wnpF:
undetectable		 3ko0M-2wnpF:
19.25
3ko0P-2wnpF:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2wnp FICOLIN-1
(Homo
sapiens) 		4 / 7 PHE F 139
GLY F 261
GLY F 135
PHE F 227
 None
 0.92A 3ko0M-2wnpF:
undetectable
3ko0P-2wnpF:
undetectable		 3ko0M-2wnpF:
19.25
3ko0P-2wnpF:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 ASP F 235
ASN F 225
SER F 239
 CA  F1298 (-2.6A)
None
None
 0.83A 3lslA-2wnpF:
undetectable
3lslD-2wnpF:
undetectable		 3lslA-2wnpF:
21.85
3lslD-2wnpF:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 SER F 239
ASP F 235
ASN F 225
 None
CA  F1298 (-2.6A)
None
 0.69A 3lslA-2wnpF:
undetectable
3lslD-2wnpF:
undetectable		 3lslA-2wnpF:
21.85
3lslD-2wnpF:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 12 GLY F 135
GLU F 156
ASN F 273
SER F 286
ILE F 275
 None
 1.23A 4pb1A-2wnpF:
undetectable		 4pb1A-2wnpF:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 SER F 100
GLU F 291
ASP F 120
 None
 0.83A 4xudA-2wnpF:
undetectable		 4xudA-2wnpF:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2wnp FICOLIN-1
(Homo
sapiens) 		3 / 3 LYS F 230
LEU F 262
ASP F 138
 None
 0.71A 5zv2A-2wnpF:
undetectable		 5zv2A-2wnpF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2wnp FICOLIN-1
(Homo
sapiens) 		5 / 12 LEU F 262
GLY F 274
HIS F 268
SER F 228
ASP F 235
 None
None
None
None
CA  F1298 (-2.6A)
 1.26A 6bxlA-2wnpF:
undetectable		 6bxlA-2wnpF:
18.57