SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A 107
VAL A 111
CYH A 114
ALA A 193
 None
 0.92A 1mz9D-2wnrA:
undetectable		 1mz9D-2wnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 LEU A 107
VAL A 111
CYH A 114
ALA A 193
 None
 0.94A 1mz9E-2wnrA:
undetectable		 1mz9E-2wnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 224
SER A 222
MET A 195
GLY B 205
SER B 203
 None
 1.26A 1nbiC-2wnrA:
undetectable		 1nbiC-2wnrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 224
SER A 222
MET A 195
GLY B 205
SER B 203
 None
 1.25A 1nbiD-2wnrA:
undetectable		 1nbiD-2wnrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLN A 235
ALA A 233
PHE A 151
GLU B 100
 None
 1.05A 1t9wA-2wnrA:
undetectable		 1t9wA-2wnrA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL B 129
GLY B 135
THR B 136
ALA B 139
 None
PO4  B1237 (-3.5A)
PO4  B1237 (-2.8A)
None
 0.65A 3aruA-2wnrB:
undetectable		 3aruA-2wnrB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU B 200
GLY A 237
ILE B 141
LEU B 109
ARG B  72
 None
 1.17A 3gyqA-2wnrB:
undetectable
3gyqB-2wnrB:
undetectable		 3gyqA-2wnrB:
23.79
3gyqB-2wnrB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 155
VAL A 159
LEU A 162
VAL A 189
 None
 0.64A 3hs6B-2wnrA:
undetectable		 3hs6B-2wnrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 ILE A  60
VAL A  53
ALA A 153
LEU A 156
ILE A 121
LEU A 163
 None
 1.21A 3mb5A-2wnrA:
undetectable		 3mb5A-2wnrA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE B 127
ILE B  31
ILE B  52
ALA B 147
LEU B 234
 None
 1.09A 3uj7B-2wnrB:
undetectable		 3uj7B-2wnrB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A 187
ILE A 115
ALA A 161
MET A 120
 None
 0.94A 4dc3B-2wnrA:
undetectable		 4dc3B-2wnrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 TYR B  79
THR B 136
GLU B 100
 None
PO4  B1237 (-2.8A)
None
 0.73A 4df3A-2wnrB:
undetectable		 4df3A-2wnrB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 TYR B  79
THR B 136
GLU B 100
 None
PO4  B1237 (-2.8A)
None
 0.74A 4df3B-2wnrB:
undetectable		 4df3B-2wnrB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 155
VAL A 159
LEU A 162
VAL A 189
 None
 0.69A 4e1gB-2wnrA:
undetectable		 4e1gB-2wnrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA B 108
THR B 199
ALA B 190
GLY A 238
GLY A 237
 None
 1.15A 4qwuK-2wnrB:
undetectable
4qwuL-2wnrB:
undetectable		 4qwuK-2wnrB:
19.68
4qwuL-2wnrB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA B 108
THR B 199
ALA B 190
GLY A 238
GLY A 237
 None
 1.08A 4qwuY-2wnrB:
undetectable
4qwuZ-2wnrB:
undetectable		 4qwuY-2wnrB:
19.68
4qwuZ-2wnrB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLU B 178
GLU B 179
GLU B 177
GLU B 133
 None
 1.25A 4r87E-2wnrB:
undetectable		 4r87E-2wnrB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ILE A 115
LEU A 194
LEU A 162
ALA A 160
CYH A 232
 None
 1.17A 5ji0A-2wnrA:
undetectable		 5ji0A-2wnrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 177
ALA A 170
THR A 165
GLY A  79
LEU A 126
 None
 1.22A 5m54E-2wnrA:
undetectable		 5m54E-2wnrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		5 / 9 VAL A 247
LEU B 207
ARG A 244
ALA B 215
ASP B 217
 None
 1.38A 6c2mB-2wnrA:
undetectable		 6c2mB-2wnrA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A  20
GLU A  33
HIS A  32
VAL A 206
 None
 1.14A 6j20A-2wnrA:
undetectable		 6j20A-2wnrA:
20.13