SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 10 LEU A   8
GLU A 181
LEU A  11
LEU A 153
GLU A 156
 None
 1.24A 1ie4A-2wnsA:
undetectable
1ie4C-2wnsA:
undetectable		 1ie4A-2wnsA:
21.94
1ie4C-2wnsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 10 LEU A 153
GLU A 156
LEU A   8
GLU A 181
LEU A  11
 None
 1.27A 1ie4A-2wnsA:
undetectable
1ie4C-2wnsA:
undetectable		 1ie4A-2wnsA:
21.94
1ie4C-2wnsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 11 VAL A 173
ILE A  56
LEU A  11
LEU A  40
LEU A  15
 None
 1.29A 2a15A-2wnsA:
undetectable		 2a15A-2wnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 7 PHE A  23
SER A  34
LEU A 180
GLY A 195
 None
 0.92A 2v0mC-2wnsA:
undetectable		 2v0mC-2wnsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ASP A 154
SER A 128
GLY A 159
ALA A 149
 None
OMP  A 450 (-2.5A)
None
None
 0.81A 4m48A-2wnsA:
undetectable		 4m48A-2wnsA:
16.79