SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wnt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.62A 1m17A-2wntA:
21.0		 1m17A-2wntA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 LEU A 604
ALA A 648
LEU A 681
ALA A 512
 None
 1.02A 1sn0B-2wntA:
undetectable
1sn0D-2wntA:
undetectable		 1sn0B-2wntA:
17.93
1sn0D-2wntA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 LEU A 681
ALA A 512
LEU A 604
ALA A 648
 None
 1.02A 1sn0B-2wntA:
undetectable
1sn0D-2wntA:
undetectable		 1sn0B-2wntA:
17.93
1sn0D-2wntA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 ASN A 540
HIS A 533
PHE A 558
ILE A 519
 None
 1.14A 1tdnA-2wntA:
undetectable		 1tdnA-2wntA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 5 ASP A 596
GLU A 593
THR A 522
LEU A 526
 None
 1.23A 1u18B-2wntA:
undetectable		 1u18B-2wntA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 ALA A 445
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.86A 1uwhA-2wntA:
20.3		 1uwhA-2wntA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.81A 1uwhB-2wntA:
20.2		 1uwhB-2wntA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 ILE A 424
LYS A 447
LEU A 463
ILE A 472
 None
 0.67A 1uwjA-2wntA:
19.8		 1uwjA-2wntA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 LEU A 497
LEU A 498
LEU A 502
ILE A 501
LEU A 604
 None
 0.95A 2bdmA-2wntA:
undetectable		 2bdmA-2wntA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		3 / 3 LEU A 487
LEU A 491
MET A 492
 None
 0.32A 2itzA-2wntA:
20.4		 2itzA-2wntA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 6 LEU A 526
ILE A 555
ILE A 501
LEU A 604
 None
 0.84A 2xkwB-2wntA:
undetectable		 2xkwB-2wntA:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ILE A 424
ALA A 445
ILE A 473
LEU A 491
MET A 492
GLY A 495
GLU A 496
 None
 0.97A 2y7jA-2wntA:
26.0		 2y7jA-2wntA:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ILE A 424
ALA A 445
LEU A 491
MET A 492
GLY A 495
GLU A 496
LEU A 542
 None
 0.94A 2y7jA-2wntA:
26.0		 2y7jA-2wntA:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 10 ILE A 424
ALA A 445
ILE A 473
LEU A 491
MET A 492
ASP A 557
 None
 0.78A 2y7jB-2wntA:
26.1		 2y7jB-2wntA:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 ALA A 512
LEU A 603
GLY A 610
HIS A 688
LEU A 686
 None
 1.11A 2yjaB-2wntA:
undetectable		 2yjaB-2wntA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 VAL A 523
THR A 522
ILE A 519
ILE A 541
 None
 0.81A 3deuA-2wntA:
undetectable		 3deuA-2wntA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 ALA A 445
GLU A 459
LEU A 463
ILE A 473
THR A 489
 None
 0.98A 3gcsA-2wntA:
18.8		 3gcsA-2wntA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 ALA A 445
LEU A 463
ILE A 473
THR A 489
HIS A 533
ASP A 557
 None
 1.08A 3gp0A-2wntA:
18.9		 3gp0A-2wntA:
29.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 ALA A 445
LEU A 463
ILE A 473
LEU A 491
ASP A 557
 None
 0.95A 3hecA-2wntA:
19.0		 3hecA-2wntA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
GLU A 459
LEU A 463
ILE A 473
THR A 489
LEU A 491
 None
 0.80A 3hecA-2wntA:
19.0		 3hecA-2wntA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 ALA A 445
LYS A 447
GLU A 459
LEU A 463
ILE A 473
THR A 489
 None
 1.01A 3hegA-2wntA:
18.9		 3hegA-2wntA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 8 PHE A 507
LEU A 498
TYR A 543
LEU A 603
 None
 0.88A 3i45A-2wntA:
undetectable		 3i45A-2wntA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 8 ALA A 445
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.95A 3lfaA-2wntA:
15.1		 3lfaA-2wntA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 8 LYS A 447
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.94A 3lfaA-2wntA:
15.1		 3lfaA-2wntA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 GLY A 425
ALA A 445
LYS A 447
LEU A 463
ILE A 473
THR A 489
 None
 0.74A 3ohtA-2wntA:
17.6		 3ohtA-2wntA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_2
(P38A)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		3 / 3 GLU A 459
LEU A 487
LEU A 491
 None
 0.70A 3ohtA-2wntA:
17.6		 3ohtA-2wntA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_2
(P38A)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		3 / 3 GLU A 459
LEU A 487
LEU A 491
 None
 0.71A 3ohtB-2wntA:
5.6		 3ohtB-2wntA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 ALA A 512
LEU A 603
GLY A 610
HIS A 688
LEU A 686
 None
 1.06A 3olsA-2wntA:
undetectable		 3olsA-2wntA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 GLY A 425
ALA A 445
LEU A 475
LEU A 487
GLY A 495
GLU A 496
LEU A 542
 None
 0.58A 4ifgA-2wntA:
25.3		 4ifgA-2wntA:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 7 LEU A 553
ASN A 471
LEU A 536
MET A 607
 None
 1.03A 4okwA-2wntA:
undetectable		 4okwA-2wntA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 PHE A 558
ALA A 561
THR A 518
THR A 522
LEU A 536
 None
 1.26A 4qynA-2wntA:
undetectable		 4qynA-2wntA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 PHE A 558
ALA A 561
THR A 518
THR A 522
LEU A 536
 None
 1.34A 4qzuA-2wntA:
undetectable		 4qzuA-2wntA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 10 ILE A 424
ALA A 445
LYS A 447
ILE A 473
THR A 489
LEU A 491
LEU A 542
 None
 0.53A 4rz7A-2wntA:
22.7		 4rz7A-2wntA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LEU A 463
GLY A 495
HIS A 533
LEU A 542
CYH A 556
ASP A 557
 None
 1.36A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LEU A 463
THR A 489
GLY A 495
HIS A 533
CYH A 556
ASP A 557
 None
 1.22A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
LEU A 463
GLY A 495
HIS A 533
LEU A 542
CYH A 556
 None
 1.18A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
LEU A 463
THR A 489
GLY A 495
HIS A 533
CYH A 556
 None
 1.00A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 6 ALA A 445
LEU A 491
MET A 492
LEU A 542
 None
 0.83A 4xoyA-2wntA:
21.4		 4xoyA-2wntA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 6 ALA A 445
LEU A 491
MET A 492
LEU A 542
 None
 0.90A 4xp3A-2wntA:
16.3		 4xp3A-2wntA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 ALA A 445
LYS A 447
LEU A 463
THR A 489
ASP A 557
PHE A 558
 None
 0.98A 4xv2B-2wntA:
20.6		 4xv2B-2wntA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 12 ALA A 512
LEU A 604
LEU A 603
GLY A 610
LEU A 686
 None
 1.06A 5gtrA-2wntA:
undetectable		 5gtrA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 12 LYS A 447
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.86A 5hi2A-2wntA:
20.7		 5hi2A-2wntA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 9 ILE A 424
GLY A 425
ALA A 445
ILE A 473
MET A 492
 None
 0.63A 5lw1B-2wntA:
19.7		 5lw1B-2wntA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		5 / 10 GLY A 425
ALA A 445
ILE A 473
LEU A 491
MET A 492
 None
 0.67A 5lw1E-2wntA:
19.4		 5lw1E-2wntA:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		4 / 8 ALA A 445
GLU A 459
LEU A 542
ASP A 557
 None
 0.73A 5owrA-2wntA:
21.5		 5owrA-2wntA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		7 / 12 ALA A 445
LYS A 447
GLU A 459
LEU A 491
GLY A 495
LEU A 542
ASP A 557
 None
 0.85A 5y7zB-2wntA:
14.4		 5y7zB-2wntA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		8 / 12 ALA A 445
LYS A 447
GLU A 459
THR A 489
LEU A 491
GLY A 495
LEU A 542
ASP A 557
 None
 0.78A 5y80A-2wntA:
22.0		 5y80A-2wntA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens) 		6 / 10 ILE A 555
ALA A 512
LEU A 497
LEU A 553
LEU A 536
LEU A 603
 None
 1.42A 6f6nA-2wntA:
undetectable
6f6nB-2wntA:
undetectable		 6f6nA-2wntA:
14.62
6f6nB-2wntA:
13.56