SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 12 LEU A 407
LEU A 440
HIS A 311
LEU A 393
ILE A  34
 None
 1.39A 1fmlA-2wnwA:
undetectable		 1fmlA-2wnwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 TRP A 144
VAL A 200
TRP A 203
 GOL  A1449 (-4.2A)
None
GOL  A1449 (-4.3A)
 1.26A 1gmkC-2wnwA:
undetectable
1gmkD-2wnwA:
undetectable		 1gmkC-2wnwA:
3.04
1gmkD-2wnwA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 7 GLY A 327
ILE A  45
ALA A 282
ILE A 278
 None
 0.63A 1n49A-2wnwA:
undetectable		 1n49A-2wnwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 11 LEU A 432
ARG A 417
VAL A 414
GLN A 415
ASP A 390
 None
 1.23A 2q6hA-2wnwA:
undetectable		 2q6hA-2wnwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 8 PHE A 328
THR A 312
ASP A 330
ILE A 370
 None
 0.91A 2qbmA-2wnwA:
undetectable		 2qbmA-2wnwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 11 LEU A 432
ARG A 417
VAL A 414
GLN A 415
ASP A 390
 None
 1.24A 2qeiA-2wnwA:
undetectable		 2qeiA-2wnwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 7 ALA A 215
THR A 214
ALA A 217
TYR A 208
 None
 0.94A 2ql8A-2wnwA:
undetectable
2ql8B-2wnwA:
undetectable		 2ql8A-2wnwA:
16.85
2ql8B-2wnwA:
16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		9 / 12 ASP A  94
TRP A 144
ASN A 195
GLU A 196
HIS A 268
TYR A 270
GLU A 294
TRP A 331
ASN A 346
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-3.7A)
GOL  A1449 ( 4.8A)
None
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
GOL  A1449 (-4.4A)
 0.38A 2v3dA-2wnwA:
49.3		 2v3dA-2wnwA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		6 / 12 ASP A  94
TRP A 144
ASN A 195
GLU A 294
TRP A 331
ASN A 342
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
None
 1.25A 2v3dA-2wnwA:
49.3		 2v3dA-2wnwA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		8 / 11 ASP A  94
TRP A 144
ASN A 195
GLU A 196
TYR A 270
GLU A 294
TRP A 331
ASN A 346
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-3.7A)
None
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
GOL  A1449 (-4.4A)
 0.36A 2v3dB-2wnwA:
49.2		 2v3dB-2wnwA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		6 / 11 ASP A  94
TRP A 144
ASN A 195
GLU A 294
TRP A 331
ASN A 342
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
None
 1.21A 2v3dB-2wnwA:
49.2		 2v3dB-2wnwA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 8 GLY A 424
ARG A  26
LEU A 422
LEU A  33
 None
 0.89A 2vctC-2wnwA:
undetectable		 2vctC-2wnwA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 TRP A 203
GLN A 194
TRP A 269
 GOL  A1449 (-4.3A)
None
None
 1.18A 2vqyA-2wnwA:
undetectable		 2vqyA-2wnwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 12 GLY A  50
SER A 293
HIS A 268
TYR A 270
ILE A 370
 None
None
GOL  A1449 ( 4.8A)
None
None
 1.17A 3g9eA-2wnwA:
undetectable		 3g9eA-2wnwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 5 LEU A 133
LYS A  68
GLN A  70
LEU A  72
 None
 1.11A 3h5gA-2wnwA:
undetectable
3h5gB-2wnwA:
undetectable		 3h5gA-2wnwA:
6.03
3h5gB-2wnwA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 9 GLY A 295
CYH A 374
PHE A 398
PHE A 328
PHE A 321
 None
 1.34A 3ko0A-2wnwA:
undetectable
3ko0C-2wnwA:
undetectable		 3ko0A-2wnwA:
12.09
3ko0C-2wnwA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 8 GLY A  47
ILE A 370
PHE A  71
PHE A  76
 None
 0.93A 3ko0B-2wnwA:
undetectable
3ko0J-2wnwA:
undetectable		 3ko0B-2wnwA:
12.09
3ko0J-2wnwA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 7 GLY A 295
PHE A 398
PHE A 328
PHE A 321
 None
 1.06A 3ko0L-2wnwA:
undetectable
3ko0N-2wnwA:
undetectable		 3ko0L-2wnwA:
12.09
3ko0N-2wnwA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 10 GLY A 295
CYH A 374
PHE A 398
PHE A 328
PHE A 321
 None
 1.39A 3ko0R-2wnwA:
undetectable
3ko0T-2wnwA:
undetectable		 3ko0R-2wnwA:
12.09
3ko0T-2wnwA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 12 ASP A 241
GLY A 272
HIS A 315
ASP A 273
GLY A 295
 None
None
None
GOL  A1448 (-4.8A)
None
 1.11A 4blvA-2wnwA:
undetectable		 4blvA-2wnwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 ARG A 405
ARG A 443
TRP A 442
 PO4  A1446 (-3.8A)
None
None
 0.99A 4cpzC-2wnwA:
undetectable		 4cpzC-2wnwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 ARG A 405
ARG A 443
TRP A 442
 PO4  A1446 (-3.8A)
None
None
 1.06A 4cpzE-2wnwA:
undetectable		 4cpzE-2wnwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 ARG A 405
ARG A 443
TRP A 442
 PO4  A1446 (-3.8A)
None
None
 0.99A 4cpzH-2wnwA:
undetectable		 4cpzH-2wnwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 ASN A  82
LEU A 333
PHE A  48
 None
 0.74A 4dajB-2wnwA:
undetectable		 4dajB-2wnwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 5 PHE A 398
PHE A 321
ILE A  45
GLY A  47
 None
 0.90A 4ejjC-2wnwA:
undetectable		 4ejjC-2wnwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 4 LEU A 178
LEU A 139
GLN A  91
GLU A 120
 None
 0.97A 4i41A-2wnwA:
1.4		 4i41A-2wnwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 7 GLU A 211
GLU A 212
TYR A 208
GLU A 213
 None
 1.36A 4r87I-2wnwA:
undetectable		 4r87I-2wnwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 12 SER A 205
GLY A 160
GLY A 159
ASN A 153
ASP A 155
 None
 1.21A 4ubeA-2wnwA:
undetectable		 4ubeA-2wnwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 5 MET A 230
MET A 233
GLU A 234
LEU A 191
 None
 1.45A 4v2oA-2wnwA:
undetectable
4v2oC-2wnwA:
undetectable		 4v2oA-2wnwA:
11.76
4v2oC-2wnwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		4 / 8 TYR A 376
GLY A 397
SER A 386
VAL A 409
 None
 0.97A 6giqL-2wnwA:
undetectable
6giqP-2wnwA:
undetectable
6giqT-2wnwA:
undetectable		 6giqL-2wnwA:
24.36
6giqP-2wnwA:
18.58
6giqT-2wnwA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		3 / 3 ASP A 104
ASP A 204
ASN A 332
 None
 0.81A 6gngB-2wnwA:
undetectable		 6gngB-2wnwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 11 TYR A 376
VAL A 406
GLY A 397
SER A 386
VAL A 409
 None
 1.27A 6hu9A-2wnwA:
undetectable
6hu9E-2wnwA:
0.0
6hu9I-2wnwA:
undetectable		 6hu9A-2wnwA:
23.55
6hu9E-2wnwA:
17.89
6hu9I-2wnwA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB
(Salmonella
enterica) 		5 / 10 TYR A 376
VAL A 406
GLY A 397
SER A 386
VAL A 409
 None
 1.27A 6hu9L-2wnwA:
undetectable
6hu9P-2wnwA:
undetectable
6hu9T-2wnwA:
undetectable		 6hu9L-2wnwA:
23.55
6hu9P-2wnwA:
17.89
6hu9T-2wnwA:
9.84