SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  15
ILE A  13
ILE A  48
THR A 111
 None
 0.87A 3deuA-2wnxA:
undetectable		 3deuA-2wnxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  89
ALA A  90
ASP A  91
THR A 147
 None
 0.78A 4eyrB-2wnxA:
undetectable		 4eyrB-2wnxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A 118
LYS A 145
ILE A 146
GLY A  89
 None
 0.88A 4hb6A-2wnxA:
undetectable		 4hb6A-2wnxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A 138
THR A  32
PRO A 115
THR A 113
 None
 1.08A 4yoaA-2wnxA:
undetectable		 4yoaA-2wnxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A  96
PHE A 116
VAL A  50
ILE A 146
 None
 0.87A 4zzbC-2wnxA:
2.2
4zzbD-2wnxA:
2.2		 4zzbC-2wnxA:
16.98
4zzbD-2wnxA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A  51
LYS A  49
GLU A  95
 None
 0.78A 5d0yA-2wnxA:
undetectable		 5d0yA-2wnxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  11
VAL A  43
LYS A 151
ILE A  48
 None
 0.88A 5of1A-2wnxA:
undetectable		 5of1A-2wnxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  11
VAL A  43
LYS A 151
ILE A  48
 None
 1.06A 5of1B-2wnxA:
undetectable		 5of1B-2wnxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wnx GLYCOSIDE HYDROLASE,
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 11 SER A  14
ILE A 114
ASN A  34
THR A 111
ILE A  96
 None
 1.20A 5y80A-2wnxA:
undetectable		 5y80A-2wnxA:
17.06