SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2woc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 VAL A 150
LEU A 293
ALA A 291
LEU A 140
VAL A 284
 None
 1.00A 1sa1A-2wocA:
undetectable
1sa1B-2wocA:
undetectable		 1sa1A-2wocA:
22.81
1sa1B-2wocA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 VAL A 150
LEU A 293
ALA A 291
LEU A 140
VAL A 284
 None
 1.01A 1sa1C-2wocA:
undetectable
1sa1D-2wocA:
undetectable		 1sa1C-2wocA:
22.81
1sa1D-2wocA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		3 / 3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-2wocA:
undetectable		 1v8bC-2wocA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 GLY A  49
GLY A  48
ALA A  25
THR A  59
GLN A  57
 None
None
None
MN  A 401 (-3.2A)
None
 1.12A 2c49A-2wocA:
undetectable		 2c49A-2wocA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 6 HIS A 176
TYR A 224
ARG A 187
GLY A 182
 None
 1.50A 2i30A-2wocA:
1.4		 2i30A-2wocA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 4 ASP A   8
LEU A  15
GLY A  12
ARG A 281
 None
 1.32A 2j2pD-2wocA:
undetectable
2j2pE-2wocA:
undetectable		 2j2pD-2wocA:
22.48
2j2pE-2wocA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 MET A 173
THR A 169
ALA A 166
LEU A 162
LEU A 221
 None
 1.14A 2qxsB-2wocA:
undetectable		 2qxsB-2wocA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 8 THR A 229
GLN A 236
ILE A 235
ASP A 228
 None
 1.07A 2xytE-2wocA:
undetectable		 2xytE-2wocA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 GLY A  16
GLY A  20
ASP A  21
LEU A 234
ASP A 263
 None
 1.04A 2zw9B-2wocA:
undetectable		 2zw9B-2wocA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 LEU A  72
LEU A 133
LEU A  66
ALA A  73
THR A 139
 None
 1.04A 3dfrA-2wocA:
undetectable		 3dfrA-2wocA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		3 / 3 ASP A  21
LEU A  17
GLN A 283
 None
 0.63A 3g4lA-2wocA:
undetectable		 3g4lA-2wocA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 11 LEU A 137
LEU A 287
GLY A  69
LEU A 133
SER A  65
 None
 1.39A 3ndvC-2wocA:
undetectable
3ndvD-2wocA:
undetectable		 3ndvC-2wocA:
23.88
3ndvD-2wocA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		3 / 3 GLU A 277
LEU A  15
LEU A  23
 None
 0.60A 3ohtA-2wocA:
undetectable		 3ohtA-2wocA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		3 / 3 GLU A 277
LEU A  15
LEU A  23
 None
 0.60A 3ohtB-2wocA:
undetectable		 3ohtB-2wocA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 8 ASP A  61
ASP A  60
GLY A  99
GLN A  57
 FMT  A 402 ( 4.1A)
FMT  A 402 ( 2.7A)
None
None
 0.87A 3s3mA-2wocA:
undetectable		 3s3mA-2wocA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 8 ASP A  61
ASP A  60
GLY A  99
GLN A  57
 FMT  A 402 ( 4.1A)
FMT  A 402 ( 2.7A)
None
None
 0.93A 3s3nA-2wocA:
undetectable		 3s3nA-2wocA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 5 LEU A  51
PRO A  95
VAL A  96
ASP A  21
 None
 1.14A 3ufnA-2wocA:
undetectable
3ufnB-2wocA:
undetectable		 3ufnA-2wocA:
15.59
3ufnB-2wocA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 8 LEU A  66
ARG A 281
VAL A 261
GLY A  12
 None
 0.93A 4klrB-2wocA:
undetectable		 4klrB-2wocA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 ILE A  58
GLY A  56
ALA A  22
ASP A  21
THR A  62
 None
 1.19A 4xt8A-2wocA:
undetectable		 4xt8A-2wocA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 ALA A 166
THR A 169
LEU A 170
GLY A 125
ALA A 128
 None
 1.18A 4ypmA-2wocA:
undetectable		 4ypmA-2wocA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 7 ALA A 255
ASP A  61
GLY A  24
GLU A  28
 None
FMT  A 402 ( 4.1A)
None
MN  A 401 (-3.1A)
 0.91A 5bs8A-2wocA:
undetectable
5bs8C-2wocA:
undetectable
5bs8D-2wocA:
undetectable		 5bs8A-2wocA:
21.33
5bs8C-2wocA:
21.33
5bs8D-2wocA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		4 / 7 ALA A 255
ASP A  61
GLY A  24
GLU A  28
 None
FMT  A 402 ( 4.1A)
None
MN  A 401 (-3.1A)
 0.91A 5btgA-2wocA:
undetectable
5btgC-2wocA:
undetectable
5btgD-2wocA:
undetectable		 5btgA-2wocA:
21.33
5btgC-2wocA:
21.33
5btgD-2wocA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 ALA A 129
LEU A 250
SER A  65
LEU A 193
ILE A 213
 None
 1.10A 5m24A-2wocA:
undetectable		 5m24A-2wocA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		3 / 3 GLU A 112
HIS A 111
ARG A 107
 None
 0.92A 5uunA-2wocA:
1.2		 5uunA-2wocA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE
(Rhodospirillum
rubrum) 		5 / 12 GLY A 248
VAL A 238
THR A  46
GLY A  47
GLY A  48
 None
 1.06A 6brdB-2wocA:
undetectable		 6brdB-2wocA:
15.50