SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2woz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 11 HIS A 440
LEU A 393
GLY A 394
TYR A 348
VAL A 350
 None
 1.13A 1axwB-2wozA:
undetectable		 1axwB-2wozA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 8 ILE A 443
PHE A 488
LYS A 455
GLY A 454
 None
 1.04A 1os6A-2wozA:
undetectable		 1os6A-2wozA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		3 / 3 GLU A 411
THR A 410
LEU A 414
 None
 0.69A 1v8bC-2wozA:
undetectable		 1v8bC-2wozA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 12 GLY A 352
GLY A 351
VAL A 402
LEU A 364
LEU A 418
 None
 0.91A 1ya4C-2wozA:
undetectable		 1ya4C-2wozA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 12 HIS A 440
TRP A 427
LEU A 393
GLY A 394
VAL A 350
 None
 1.24A 2kceB-2wozA:
undetectable		 2kceB-2wozA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 6 LEU A 540
TYR A 545
VAL A 538
ASP A 567
 None
 0.89A 3cs9D-2wozA:
undetectable		 3cs9D-2wozA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 8 TYR A 545
LEU A 308
CYH A 593
TYR A 317
 None
 1.29A 3po7A-2wozA:
undetectable		 3po7A-2wozA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 8 ILE A 443
PHE A 488
LYS A 455
GLY A 454
 None
 1.00A 3selX-2wozA:
undetectable		 3selX-2wozA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 7 ILE A 443
PHE A 488
LYS A 455
GLY A 454
 None
 1.10A 3sj0X-2wozA:
undetectable		 3sj0X-2wozA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 9 ILE A 499
GLY A 489
PHE A 488
VAL A 465
GLY A 453
 None
 1.19A 4acaB-2wozA:
undetectable
4acaC-2wozA:
undetectable		 4acaB-2wozA:
21.93
4acaC-2wozA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 9 VAL A 512
ILE A 535
GLY A 502
SER A 509
ALA A 510
 None
 1.10A 4fwdA-2wozA:
undetectable		 4fwdA-2wozA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 7 ILE A 443
PHE A 488
LYS A 455
GLY A 454
 None
 1.06A 4hbfA-2wozA:
undetectable		 4hbfA-2wozA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 11 VAL A 442
ASN A 441
PHE A 488
GLY A 453
SER A 338
 None
 1.12A 4zbqA-2wozA:
undetectable		 4zbqA-2wozA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 11 VAL A 442
ASN A 441
PHE A 488
GLY A 454
SER A 338
 None
 1.36A 4zbqA-2wozA:
undetectable		 4zbqA-2wozA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		4 / 6 ILE A 535
VAL A 512
PRO A 529
ALA A 500
 None
 0.82A 5cu6A-2wozA:
undetectable		 5cu6A-2wozA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		5 / 12 GLY A 548
ILE A 568
ALA A 546
ALA A 591
CYH A 593
 None
 0.99A 6bq4A-2wozA:
undetectable		 6bq4A-2wozA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10
(Rattus
norvegicus) 		3 / 3 THR A 596
GLU A 395
ASN A 345
 None
 0.71A 6nj9K-2wozA:
undetectable		 6nj9K-2wozA:
21.56