SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 1.05A 1v55P-2wp0A:
undetectable
1v55W-2wp0A:
undetectable		 1v55P-2wp0A:
20.15
1v55W-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 1.02A 2dysC-2wp0A:
undetectable
2dysJ-2wp0A:
undetectable		 2dysC-2wp0A:
20.15
2dysJ-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2wp0 HOBA
(Helicobacter
pylori) 		4 / 7 ILE A  65
PHE A 166
ILE A  37
PHE A 134
 None
 1.20A 2qb4A-2wp0A:
undetectable		 2qb4A-2wp0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2wp0 HOBA
(Helicobacter
pylori) 		5 / 10 TYR A  91
SER A  53
HIS A 114
GLY A 122
ILE A 126
 CL  A 203 (-3.9A)
None
None
None
None
 1.48A 2zm8A-2wp0A:
0.0		 2zm8A-2wp0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 2wp0 CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori) 		5 / 12 ALA C  39
ASN C  36
PRO C  37
GLU C  88
TYR C  48
 None
 1.24A 4xqeB-2wp0C:
undetectable		 4xqeB-2wp0C:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2wp0 HOBA
(Helicobacter
pylori) 		4 / 8 HIS A  43
PRO A 110
LEU A  50
LEU A  51
 None
 1.21A 5dzkd-2wp0A:
1.9
5dzkr-2wp0A:
undetectable		 5dzkd-2wp0A:
20.64
5dzkr-2wp0A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2wp0 CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
HOBA
(Helicobacter
pylori) 		4 / 8 PRO A  78
THR C  56
THR C  57
TYR C  29
 None
 1.09A 5x2sI-2wp0A:
undetectable
5x2sJ-2wp0A:
undetectable
5x2sK-2wp0A:
undetectable		 5x2sI-2wp0A:
22.75
5x2sJ-2wp0A:
21.08
5x2sK-2wp0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.80A 5z84C-2wp0A:
undetectable
5z84J-2wp0A:
undetectable		 5z84C-2wp0A:
20.15
5z84J-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.79A 5z85C-2wp0A:
undetectable
5z85J-2wp0A:
undetectable		 5z85C-2wp0A:
20.15
5z85J-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.76A 5zcoC-2wp0A:
undetectable
5zcoJ-2wp0A:
undetectable		 5zcoC-2wp0A:
20.15
5zcoJ-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.86A 5zcqC-2wp0A:
undetectable
5zcqJ-2wp0A:
undetectable		 5zcqC-2wp0A:
20.15
5zcqJ-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 7 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.81A 5zcqP-2wp0A:
undetectable
5zcqW-2wp0A:
undetectable		 5zcqP-2wp0A:
20.15
5zcqW-2wp0A:
15.17