SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		3 / 3 GLN A 271
LYS A 264
VAL A 262
 None
 0.85A 2jfaB-2wp1A:
undetectable		 2jfaB-2wp1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 6 GLU A 378
ALA A 337
PRO A 379
ALA A 333
 None
 1.20A 2zgwB-2wp1A:
undetectable		 2zgwB-2wp1A:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 7 TRP A 292
PRO A 293
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.70A 3u5jA-2wp1A:
16.7		 3u5jA-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
PRO A 293
VAL A 298
LEU A 305
ASN A 351
MET A 360
 None
 0.58A 3u5kA-2wp1A:
16.8		 3u5kA-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
VAL A 298
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.65A 3u5kA-2wp1A:
16.8		 3u5kA-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 7 TRP A 292
PRO A 293
VAL A 298
LEU A 305
ASN A 351
 None
 0.63A 3u5kB-2wp1A:
16.8		 3u5kB-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 7 TRP A 292
VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.68A 3u5kB-2wp1A:
16.8		 3u5kB-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
PRO A 293
VAL A 298
LEU A 305
ASN A 351
MET A 360
 None
 0.62A 3u5kC-2wp1A:
16.6		 3u5kC-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
VAL A 298
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.76A 3u5kC-2wp1A:
16.6		 3u5kC-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
PRO A 293
VAL A 298
LEU A 305
ASN A 351
MET A 360
 None
 0.62A 3u5kD-2wp1A:
16.8		 3u5kD-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
VAL A 298
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.77A 3u5kD-2wp1A:
16.8		 3u5kD-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 5 VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.41A 4a9jA-2wp1A:
18.2		 4a9jA-2wp1A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 5 VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.43A 4a9jB-2wp1A:
18.2		 4a9jB-2wp1A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 5 VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.38A 4a9jC-2wp1A:
18.1		 4a9jC-2wp1A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 6 VAL A 298
LEU A 303
TYR A 350
ASN A 351
VAL A 357
 None
 0.40A 4a9kA-2wp1A:
17.5		 4a9kA-2wp1A:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 5 VAL A 298
LEU A 303
ASN A 351
VAL A 357
 None
 0.69A 4a9kB-2wp1A:
17.3		 4a9kB-2wp1A:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		7 / 9 TRP A 292
PRO A 293
VAL A 298
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.66A 4c66A-2wp1A:
16.8		 4c66A-2wp1A:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 TRP A 292
VAL A 298
LEU A 303
LEU A 305
TYR A 350
ASN A 351
 None
 0.78A 4lzrA-2wp1A:
16.6		 4lzrA-2wp1A:
38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 12 PRO A 379
PHE A 372
ILE A 375
HIS A 274
VAL A 268
 None
 1.36A 4yfbC-2wp1A:
0.0		 4yfbC-2wp1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 12 PRO A 379
PHE A 372
ILE A 375
HIS A 274
VAL A 268
 None
 1.37A 4yfbF-2wp1A:
0.0		 4yfbF-2wp1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 12 PRO A 379
PHE A 372
ILE A 375
HIS A 274
VAL A 268
 None
 1.36A 4yfbI-2wp1A:
undetectable		 4yfbI-2wp1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		5 / 12 PRO A 379
PHE A 372
ILE A 375
HIS A 274
VAL A 268
 None
 1.36A 4yfbL-2wp1A:
0.5		 4yfbL-2wp1A:
11.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		4 / 6 PRO A 293
VAL A 298
TYR A 308
ASN A 351
 None
 0.81A 5pbeA-2wp1A:
16.6		 5pbeA-2wp1A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 PRO A 293
VAL A 298
LEU A 305
CYH A 347
TYR A 350
ASN A 351
 None
 0.57A 5y1yA-2wp1A:
16.9		 5y1yA-2wp1A:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Mus
musculus) 		6 / 8 VAL A 298
LEU A 303
LEU A 305
CYH A 347
TYR A 350
ASN A 351
 None
 0.50A 5y1yA-2wp1A:
16.9		 5y1yA-2wp1A:
38.46