SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 125
VAL A  87
ILE A 121
MET A  70
 None
 1.11A 1iepA-2wp4A:
undetectable		 1iepA-2wp4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 5 SER A 106
ARG A  84
PRO A  32
GLY A  31
 None
 1.29A 2y7kB-2wp4A:
undetectable		 2y7kB-2wp4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 6 SER A 106
ARG A  84
PRO A  32
GLY A  31
 None
 1.34A 2y7pA-2wp4A:
undetectable		 2y7pA-2wp4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 125
VAL A  87
ILE A 121
MET A  70
 None
 1.12A 3mssA-2wp4A:
undetectable		 3mssA-2wp4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 125
VAL A  87
ILE A 121
MET A  70
 None
 1.10A 3mssC-2wp4A:
undetectable		 3mssC-2wp4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  98
ASN A  43
ALA A 100
TYR A  58
 None
 1.18A 4mdaA-2wp4A:
undetectable		 4mdaA-2wp4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  28
GLU A  24
ALA A 105
GLY A 104
ALA A  86
 None
GOL  A1138 (-2.7A)
None
None
None
 1.11A 5lf3H-2wp4A:
undetectable
5lf3I-2wp4A:
undetectable		 5lf3H-2wp4A:
21.49
5lf3I-2wp4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  28
GLU A  24
ALA A 105
GLY A 104
ALA A  86
 None
GOL  A1138 (-2.7A)
None
None
None
 1.14A 5lf3V-2wp4A:
undetectable
5lf3W-2wp4A:
undetectable		 5lf3V-2wp4A:
21.49
5lf3W-2wp4A:
21.53