SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 11 LEU J 292
VAL J 290
GLY J 276
VAL J 393
VAL J 392
 None
 1.24A 1akdA-2wp8J:
undetectable		 1akdA-2wp8J:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 LEU J 604
PRO J 605
LEU J 608
 None
 0.47A 1hrkA-2wp8J:
undetectable		 1hrkA-2wp8J:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU J 733
VAL J 566
VAL J 626
GLY J 567
LEU J 684
 None
 1.32A 1lwfA-2wp8J:
undetectable		 1lwfA-2wp8J:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 8 GLY J 271
GLY J 267
GLY J 266
LEU J 268
 None
 0.59A 1qzzA-2wp8J:
undetectable		 1qzzA-2wp8J:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 6 ASP J 335
VAL J 333
ILE J 332
TYR J 462
 None
 0.94A 1s9qA-2wp8J:
undetectable		 1s9qA-2wp8J:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 11 LEU J 292
VAL J 290
GLY J 276
VAL J 393
VAL J 392
 None
 1.26A 2a1nA-2wp8J:
undetectable		 2a1nA-2wp8J:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 10 LEU J 292
VAL J 290
GLY J 276
VAL J 393
VAL J 392
 None
 1.29A 2cp4A-2wp8J:
undetectable		 2cp4A-2wp8J:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 11 LEU J 407
VAL J 434
ILE J 453
VAL J 422
VAL J 424
 None
 0.90A 2nnpB-2wp8J:
undetectable		 2nnpB-2wp8J:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 LEU J 431
PRO J 432
LEU J 426
 None
GOL  J2002 ( 4.1A)
None
 0.56A 2po7B-2wp8J:
undetectable		 2po7B-2wp8J:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 7 LEU J 286
LEU J 334
PHE J 285
TYR J 462
 None
None
GOL  J2002 (-4.5A)
None
 0.86A 2vq5B-2wp8J:
undetectable		 2vq5B-2wp8J:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 4 VAL J 577
ARG J 590
ILE J 884
THR J 581
 None
 1.32A 3cl9A-2wp8J:
2.2		 3cl9A-2wp8J:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 LEU J 431
PRO J 432
LEU J 426
 None
GOL  J2002 ( 4.1A)
None
 0.36A 3hcrA-2wp8J:
undetectable		 3hcrA-2wp8J:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 12 VAL J 302
GLY J 303
LEU J 307
ILE J 332
ILE J 379
 None
None
GOL  J2002 ( 4.1A)
None
None
 1.05A 3ijdA-2wp8J:
undetectable		 3ijdA-2wp8J:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 12 VAL J 302
GLY J 303
LEU J 307
ILE J 332
ILE J 379
 None
None
GOL  J2002 ( 4.1A)
None
None
 0.97A 3ijdB-2wp8J:
undetectable		 3ijdB-2wp8J:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 12 ILE J  99
VAL J 113
ILE J 174
VAL J 117
VAL J 121
 None
 1.04A 3iw1A-2wp8J:
undetectable		 3iw1A-2wp8J:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 PHE J 829
TYR J 820
LEU J 834
 None
 0.75A 3keeB-2wp8J:
undetectable		 3keeB-2wp8J:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 VAL J 805
SER J 809
LEU J 790
 None
 0.55A 3n8xA-2wp8J:
undetectable		 3n8xA-2wp8J:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 PHE J 829
TYR J 820
LEU J 834
 None
 0.65A 3sueB-2wp8J:
undetectable		 3sueB-2wp8J:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 8 TRP J 180
HIS J 184
PHE J 148
PRO J  68
 None
 1.42A 3v35A-2wp8J:
undetectable		 3v35A-2wp8J:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 ARG J 294
THR J 389
TRP J 326
 None
 1.17A 4d7hA-2wp8J:
undetectable		 4d7hA-2wp8J:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 6 ASP J 335
ASP J 942
ASP J 988
GLU J 337
 None
 1.35A 4gkhJ-2wp8J:
undetectable		 4gkhJ-2wp8J:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 8 SER J 410
LEU J 444
ALA J 442
LEU J 407
 None
 1.01A 4ikjA-2wp8J:
undetectable
4ikjB-2wp8J:
undetectable		 4ikjA-2wp8J:
8.68
4ikjB-2wp8J:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 12 ILE J 449
GLY J 405
PHE J 467
VAL J 424
ILE J 436
 None
 0.91A 4rvdA-2wp8J:
undetectable		 4rvdA-2wp8J:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 12 ILE J 449
GLY J 405
PHE J 467
VAL J 424
ILE J 436
 None
 0.92A 4rvgA-2wp8J:
undetectable		 4rvgA-2wp8J:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 ARG J 294
THR J 389
TRP J 326
 None
 1.18A 4uglA-2wp8J:
undetectable		 4uglA-2wp8J:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 10 GLY J 934
VAL J 935
GLU J 900
VAL J 930
LEU J 998
 None
 1.26A 4yb6A-2wp8J:
undetectable
4yb6E-2wp8J:
undetectable		 4yb6A-2wp8J:
16.07
4yb6E-2wp8J:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 10 GLY J 934
VAL J 935
GLU J 900
VAL J 930
LEU J 998
 None
 1.26A 4yb6B-2wp8J:
undetectable
4yb6C-2wp8J:
undetectable		 4yb6B-2wp8J:
16.07
4yb6C-2wp8J:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 10 LEU J 998
GLY J 934
VAL J 935
GLU J 900
VAL J 930
 None
 1.26A 4yb6B-2wp8J:
undetectable
4yb6F-2wp8J:
undetectable		 4yb6B-2wp8J:
16.07
4yb6F-2wp8J:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU J 292
VAL J 290
GLY J 276
VAL J 393
VAL J 392
 None
 1.23A 5cp4A-2wp8J:
undetectable		 5cp4A-2wp8J:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 ASN J 150
ALA J 173
ARG J 169
 None
 0.79A 5cvtB-2wp8J:
undetectable		 5cvtB-2wp8J:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 PRO J 759
ILE J 807
SER J 296
 None
 0.65A 5fsaA-2wp8J:
undetectable		 5fsaA-2wp8J:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 7 ILE J 425
ILE J 449
ILE J 436
LEU J 444
 None
 0.62A 5fukA-2wp8J:
undetectable
5fukB-2wp8J:
undetectable		 5fukA-2wp8J:
14.72
5fukB-2wp8J:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 ARG J 294
THR J 389
TRP J 326
 None
 1.19A 5g6cA-2wp8J:
undetectable		 5g6cA-2wp8J:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		4 / 6 GLU J 506
GLY J 507
PHE J 576
ARG J 621
 None
 1.45A 5jcnB-2wp8J:
undetectable		 5jcnB-2wp8J:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		5 / 11 VAL J 836
ALA J 691
LEU J 732
GLU J 729
ALA J 693
 None
 1.38A 6dk1B-2wp8J:
undetectable		 6dk1B-2wp8J:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 LEU J 334
SER J 336
PHE J 339
 None
 0.55A 6fgcA-2wp8J:
undetectable		 6fgcA-2wp8J:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3
(Saccharomyces
cerevisiae) 		3 / 3 ASP J 947
ASP J 367
ASN J 197
 None
 0.72A 6gngB-2wp8J:
undetectable		 6gngB-2wp8J:
20.64