SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 ASN B  68
LEU B  39
LEU B   3
ILE B   7
 None
 1.00A 1z95A-2wp9B:
undetectable		 1z95A-2wp9B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 PHE B 162
SER B 156
ASP B 199
LEU B 197
LEU B 176
 None
None
None
None
SF4  B 303 ( 4.7A)
 1.15A 3lcvB-2wp9B:
undetectable		 3lcvB-2wp9B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 8 SER B  50
ARG B 101
GLN B  21
ASP B  46
 None
 1.32A 3n62A-2wp9B:
undetectable		 3n62A-2wp9B:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 5 LEU B  97
GLY B  96
PHE B 110
ASN B  71
 None
 1.22A 3uq6B-2wp9B:
undetectable		 3uq6B-2wp9B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 5 LEU B  39
ILE B  79
MET B  33
PHE B   5
 None
 1.09A 4dc3B-2wp9B:
undetectable		 4dc3B-2wp9B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 ILE B  40
MET B  33
ARG B  31
 None
 0.78A 4lnwA-2wp9B:
undetectable		 4lnwA-2wp9B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 ILE B  40
MET B  33
ARG B  31
 None
 0.79A 4lnxA-2wp9B:
undetectable		 4lnxA-2wp9B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 ASP B  32
LEU B  65
ASP B  63
ALA B  38
PHE B   5
 None
None
FES  B 302 (-2.2A)
None
None
 1.18A 5hnzB-2wp9B:
undetectable		 5hnzB-2wp9B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 8 SER B  50
ARG B 101
GLN B  21
ASP B  46
 None
 1.33A 5vunB-2wp9B:
undetectable		 5vunB-2wp9B:
19.42