SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		7 / 8 HIS S  57
ASP S 189
SER S 190
GLN S 192
SER S 195
GLY S 216
GLY S 226
 None
 0.82A 1aq7A-2wpmS:
36.0		 1aq7A-2wpmS:
41.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 9 ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
 None
 0.45A 1bcuH-2wpmS:
35.7		 1bcuH-2wpmS:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 9 HIS S  57
ASP S 189
SER S 195
TRP S 215
GLY S 226
 None
 0.57A 1dwcH-2wpmS:
35.2		 1dwcH-2wpmS:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		6 / 12 HIS S  57
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
 None
 0.72A 1etrH-2wpmS:
34.5		 1etrH-2wpmS:
39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 8 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.32A 1f5lA-2wpmS:
33.8		 1f5lA-2wpmS:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 10 SER S 195
SER S 214
ILE S 212
GLY S 211
GLY S 226
 None
 1.30A 1mehA-2wpmS:
undetectable		 1mehA-2wpmS:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 10 GLY S  43
PHE S  41
GLY S 193
THR S  54
VAL S  32
 None
 1.32A 1pwyE-2wpmS:
undetectable		 1pwyE-2wpmS:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL S 154
ASN S  72
GLU S  77
GLU S  74
ASP S  21
 None
None
CA  S1246 (-2.4A)
None
None
 1.35A 1t6zB-2wpmS:
undetectable		 1t6zB-2wpmS:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 6 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.25A 1tnlA-2wpmS:
36.0		 1tnlA-2wpmS:
41.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 10 GLY S  43
PHE S  41
GLY S 193
THR S  54
VAL S  32
 None
 1.25A 1v3qE-2wpmS:
undetectable		 1v3qE-2wpmS:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY S 140
PHE S  41
GLY S 193
GLY S 142
ALA S 152
 None
 1.13A 2dpmA-2wpmS:
undetectable		 2dpmA-2wpmS:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 10 ILE S 123
LEU S 105
VAL S  47
VAL S 231
ILE S 103
 None
 0.98A 2nnjA-2wpmS:
undetectable		 2nnjA-2wpmS:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 6 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.19A 2otvA-2wpmS:
36.2		 2otvA-2wpmS:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY S 142
GLY S  44
GLY S 197
ILE S  52
VAL S  31
 None
 0.96A 2oxtA-2wpmS:
undetectable		 2oxtA-2wpmS:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		8 / 12 TYR S  99
PHE S 174
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
TYR S 228
 None
 0.45A 2p16A-2wpmS:
38.9		 2p16A-2wpmS:
46.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 8 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.30A 2vinA-2wpmS:
15.3		 2vinA-2wpmS:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		8 / 12 TYR S  99
PHE S 174
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
TYR S 228
 None
 0.44A 2w26A-2wpmS:
38.9		 2w26A-2wpmS:
46.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.08A 3bjwA-2wpmS:
undetectable		 3bjwA-2wpmS:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.12A 3bjwG-2wpmS:
undetectable		 3bjwG-2wpmS:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.13A 3bjwC-2wpmS:
undetectable		 3bjwC-2wpmS:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.06A 3bjwD-2wpmS:
undetectable		 3bjwD-2wpmS:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		8 / 11 HIS S  57
ASP S 189
SER S 190
GLN S 192
SER S 195
TRP S 215
GLY S 216
GLY S 226
 None
 0.71A 3gy3A-2wpmS:
13.4		 3gy3A-2wpmS:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU S 106
GLY S  43
GLY S  44
SER S 190
ASP S 102
 None
 1.13A 3i5uB-2wpmS:
undetectable		 3i5uB-2wpmS:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 6 SER S 190
SER S 195
TRP S 215
GLY S 216
GLY S 226
 None
 0.43A 3rxfA-2wpmS:
14.2		 3rxfA-2wpmS:
41.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ASP S 189
SER S 190
SER S 195
GLY S 226
 None
 0.35A 3rxhA-2wpmS:
36.1		 3rxhA-2wpmS:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLU S 217
GLY S 216
TYR S  99
ASP S 102
 None
 1.35A 3w9tD-2wpmS:
undetectable		 3w9tD-2wpmS:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		4 / 6 PHE S 184
GLY S 136
LEU S 158
VAL S 138
 None
 0.95A 4dubB-2wpmS:
undetectable		 4dubB-2wpmS:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER S 139
GLY S 211
SER S  45
THR S 229
VAL S 200
 None
 0.98A 5kocB-2wpmS:
undetectable		 5kocB-2wpmS:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY S 142
GLY S 196
GLY S  43
GLY S 140
PHE S  94
 None
 0.95A 5vimA-2wpmS:
undetectable		 5vimA-2wpmS:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY S 226
VAL S  53
GLY S 196
SER S 195
ILE S 212
 None
 1.06A 5vopA-2wpmS:
undetectable		 5vopA-2wpmS:
21.67