SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  71
ASN A  78
ASP A  48
GLY A  49
PHE A  40
 None
 1.41A 1ju6C-2wptA:
undetectable		 1ju6C-2wptA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  71
ASN A  78
ASP A  48
GLY A  49
PHE A  40
 None
 1.39A 1jujA-2wptA:
undetectable		 1jujA-2wptA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  71
ASN A  78
ASP A  48
GLY A  49
PHE A  40
 None
 1.39A 1jujB-2wptA:
undetectable		 1jujB-2wptA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  71
ASN A  78
ASP A  48
GLY A  49
PHE A  40
 None
 1.39A 1jujC-2wptA:
undetectable		 1jujC-2wptA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  71
ASN A  78
ASP A  48
GLY A  49
PHE A  40
 None
 1.39A 1jujD-2wptA:
undetectable		 1jujD-2wptA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A  55
ASP A  62
ASP A  58
 None
 0.99A 3ou7B-2wptA:
undetectable		 3ou7B-2wptA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A  42
LEU A  43
GLU A  45
 NO3  A1087 (-3.6A)
None
None
 0.63A 4l3gF-2wptA:
undetectable		 4l3gF-2wptA:
11.37