SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2wpw ORF14
(Streptomyces
clavuligerus) 		5 / 12 ALA A 247
GLY A 239
THR A 238
THR A 184
VAL A 271
 None
 1.04A 2zifA-2wpwA:
undetectable		 2zifA-2wpwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2wpw ORF14
(Streptomyces
clavuligerus) 		4 / 6 LYS A 285
LEU A 289
GLU A 290
LEU A 169
 None
 0.88A 3h5gA-2wpwA:
undetectable
3h5gC-2wpwA:
undetectable		 3h5gA-2wpwA:
6.82
3h5gC-2wpwA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wpw ORF14
(Streptomyces
clavuligerus) 		4 / 6 HIS A 108
VAL A  92
LEU A  50
LEU A  27
 None
ACO  A 401 (-3.9A)
None
None
 0.94A 3kk6A-2wpwA:
undetectable		 3kk6A-2wpwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2wpw ORF14
(Streptomyces
clavuligerus) 		5 / 12 GLY A 250
GLY A 239
ASN A 288
VAL A 241
LEU A 200
 None
 1.09A 3p2kB-2wpwA:
undetectable		 3p2kB-2wpwA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2wpw ORF14
(Streptomyces
clavuligerus) 		5 / 12 ARG A 118
ALA A  56
PHE A 224
ARG A 228
LEU A  78
 None
 1.03A 4uw0A-2wpwA:
2.1		 4uw0A-2wpwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2wpw ORF14
(Streptomyces
clavuligerus) 		6 / 12 GLY A 281
LEU A 320
VAL A 271
ALA A 287
LEU A 284
ALA A 240
 None
 1.49A 5kpcA-2wpwA:
undetectable		 5kpcA-2wpwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2wpw ORF14
(Streptomyces
clavuligerus) 		3 / 3 HIS A 275
HIS A 272
ARG A 273
 None
 1.14A 6b58A-2wpwA:
undetectable		 6b58A-2wpwA:
22.03